Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2583459..2585047 Replicon chromosome
Accession NZ_CP098175
Organism Klebsiella pneumoniae strain Z0117KP0001

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag NBY29_RS12520 Protein ID WP_023301940.1
Coordinates 2583725..2585047 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBY29_RS12515 Protein ID WP_024622638.1
Coordinates 2583459..2583725 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY29_RS12490 (2578610) 2578610..2579533 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
NBY29_RS12495 (2579514) 2579514..2580668 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY29_RS12500 (2581014) 2581014..2582393 + 1380 WP_023301941.1 nucleobase:cation symporter-2 family protein -
NBY29_RS12505 (2582371) 2582371..2582871 + 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY29_RS12510 (2582868) 2582868..2583194 + 327 WP_004184023.1 hydroxyisourate hydrolase -
NBY29_RS12515 (2583459) 2583459..2583725 + 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY29_RS12520 (2583725) 2583725..2585047 + 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY29_RS12525 (2585064) 2585064..2586356 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY29_RS12530 (2586498) 2586498..2587502 - 1005 WP_023301939.1 fimbrial protein -
NBY29_RS12535 (2587490) 2587490..2589991 - 2502 WP_023301938.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T246812 WP_023301940.1 NZ_CP098175:2583725-2585047 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT246812 WP_024622638.1 NZ_CP098175:2583459-2583725 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure

References