Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 44686..45311 Replicon chromosome
Accession NZ_CP098175
Organism Klebsiella pneumoniae strain Z0117KP0001

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NBY29_RS00205 Protein ID WP_002882817.1
Coordinates 44928..45311 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NBY29_RS00200 Protein ID WP_004150355.1
Coordinates 44686..44928 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY29_RS00175 (40677) 40677..41276 + 600 WP_004151865.1 glucose-1-phosphatase -
NBY29_RS00180 (41270) 41270..42130 + 861 WP_004146232.1 virulence factor BrkB family protein -
NBY29_RS00185 (42127) 42127..42564 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NBY29_RS00190 (42609) 42609..43550 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NBY29_RS00195 (43564) 43564..44481 - 918 WP_023302328.1 alpha/beta hydrolase -
NBY29_RS00200 (44686) 44686..44928 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NBY29_RS00205 (44928) 44928..45311 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY29_RS00210 (45485) 45485..46414 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NBY29_RS00215 (46411) 46411..47046 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NBY29_RS00220 (47043) 47043..47945 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T246807 WP_002882817.1 NZ_CP098175:44928-45311 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT246807 WP_004150355.1 NZ_CP098175:44686-44928 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References