Detailed information of TA system TA024679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2866434..2866887
• Replicon: chromosome
• Accession: NC_013961
• Organism: Erwinia amylovora CFBP1430

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EAMY_RS30205
• Protein ID: WP_013035888.1
• Coordinates: 2866434..2866670 (-)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: EAMY_RS30210
• Protein ID: WP_004159527.1
• Coordinates: 2866660..2866887 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAMY_RS30185	2861949..2862827	-	879	WP_004159509.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-
EAMY_RS30190	2862842..2863636	-	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
EAMY_RS30195	2863685..2865901	-	2217	Protein_2501	ferrichrome porin FhuA	-
EAMY_RS30200	2866229..2866447	+	219	WP_004159522.1	hypothetical protein	-
EAMY_RS30205	2866434..2866670	-	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EAMY_RS30210	2866660..2866887	-	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EAMY_RS30215	2867208..2867495	+	288	WP_004159528.1	SymE family type I addiction module toxin	-
EAMY_RS30220	2867559..2868062	-	504	WP_048901601.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T24679 WP_013035888.1 NC_013961:c2866670-2866434 [Erwinia amylovora CFBP1430]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T24679 NC_013961:c2866670-2866434 [Erwinia amylovora CFBP1430]
ATAAGCTATGAACTGCTCTTCGATCCCTGGGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAACAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCTGCAGGTGGAATCAGCCAGGCTGAGAGATCACCCGGACTGCTGCAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTAATGTTGGTTATAAGCGTTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT24679 WP_004159527.1 NC_013961:c2866887-2866660 [Erwinia amylovora CFBP1430]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT24679 NC_013961:c2866887-2866660 [Erwinia amylovora CFBP1430]
GTGCGGCTGGATGACAAACTGAAAAGCAAAGCCTGTGCAGTTCTGGATGAACTGGATGTATCGCCAACGGAGGCGGTCCG
GCTGTTGTTCCAGTATATAGCGGAAAATGAGCGCCTACCGCTGAAAGCGCTGACGGTAAGTGATGAAAAAGACGCGCTGC
TGAAAACGGTTCGCGAAAGGCTGGCATCGCTACAGAAGGGAATAAAGGTAACGCTGGATAAGCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A831A410