246542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 171290..172309 Replicon chromosome
Accession NZ_CP098025
Organism Enterococcus faecalis strain QZ076

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag NAG05_RS00840 Protein ID WP_137274387.1
Coordinates 171290..171928 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag NAG05_RS00845 Protein ID WP_002359284.1
Coordinates 171935..172309 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG05_RS00820 (166595) 166595..166873 - 279 WP_225583231.1 hypothetical protein -
NAG05_RS00825 (167630) 167630..167947 + 318 WP_002397676.1 helix-turn-helix transcriptional regulator -
NAG05_RS00830 (168062) 168062..169927 + 1866 WP_010716723.1 DUF262 domain-containing protein -
NAG05_RS00835 (170673) 170673..171248 + 576 WP_002359282.1 restriction endonuclease -
NAG05_RS00840 (171290) 171290..171928 - 639 WP_137274387.1 ImmA/IrrE family metallo-endopeptidase Toxin
NAG05_RS00845 (171935) 171935..172309 - 375 WP_002359284.1 helix-turn-helix domain-containing protein Antitoxin
NAG05_RS00850 (173153) 173153..173335 - 183 WP_129217660.1 hypothetical protein -
NAG05_RS00855 (173502) 173502..173753 + 252 WP_002359287.1 hypothetical protein -
NAG05_RS00860 (173840) 173840..174166 + 327 WP_002359288.1 hypothetical protein -
NAG05_RS00865 (174166) 174166..174573 + 408 WP_137274388.1 DUF961 family protein -
NAG05_RS00870 (174728) 174728..174952 + 225 WP_137274389.1 hypothetical protein -
NAG05_RS00875 (174981) 174981..175172 + 192 WP_137274394.1 hypothetical protein -
NAG05_RS00880 (175154) 175154..175558 + 405 WP_137274390.1 hypothetical protein -
NAG05_RS00885 (175670) 175670..176002 + 333 WP_137274391.1 nucleotidyltransferase domain-containing protein -
NAG05_RS00890 (175992) 175992..176375 + 384 WP_002359294.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tufA 156134..236071 79937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(86-176)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-61)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 25202.20 Da        Isoelectric Point: 9.1676

>T246542 WP_137274387.1 NZ_CP098025:c171928-171290 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDIPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILFK

Download         Length: 639 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14518.29 Da        Isoelectric Point: 4.8896

>AT246542 WP_002359284.1 NZ_CP098025:c172309-171935 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References