Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 991732..993376 Replicon chromosome
Accession NZ_CP097896
Organism Pectobacterium actinidiae strain GX-Pa1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M9782_RS04450 Protein ID WP_275071734.1
Coordinates 992042..993376 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C6CLK4
Locus tag M9782_RS04445 Protein ID WP_015848020.1
Coordinates 991732..992037 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9782_RS04410 (M9782_04410) 986844..987164 + 321 WP_275071733.1 TA system toxin CbtA family protein -
M9782_RS04415 (M9782_04415) 987282..988115 + 834 WP_261850159.1 DUF4942 domain-containing protein -
M9782_RS04420 (M9782_04420) 988225..988467 + 243 WP_261850158.1 ribbon-helix-helix domain-containing protein -
M9782_RS04425 (M9782_04425) 988640..989035 + 396 WP_261850157.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
M9782_RS04430 (M9782_04430) 989028..989975 + 948 WP_261850156.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
M9782_RS04435 (M9782_04435) 990365..991228 + 864 Protein_855 integrase arm-type DNA-binding domain-containing protein -
M9782_RS04440 (M9782_04440) 991295..991426 + 132 Protein_856 CopG family transcriptional regulator -
M9782_RS04445 (M9782_04445) 991732..992037 + 306 WP_015848020.1 helix-turn-helix transcriptional regulator Antitoxin
M9782_RS04450 (M9782_04450) 992042..993376 + 1335 WP_275071734.1 type II toxin-antitoxin system HipA family toxin Toxin
M9782_RS04455 (M9782_04455) 993653..993775 - 123 Protein_859 transcriptional regulator -
M9782_RS04460 (M9782_04460) 994049..994477 + 429 WP_275071735.1 GNAT family N-acetyltransferase -
M9782_RS04465 (M9782_04465) 994568..995689 + 1122 WP_275071736.1 cupin domain-containing protein -
M9782_RS04470 (M9782_04470) 995987..997132 + 1146 WP_275071737.1 alpha/beta hydrolase -
M9782_RS04475 (M9782_04475) 997163..998353 - 1191 WP_275071738.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 960820..994477 33657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50915.05 Da        Isoelectric Point: 6.0228

>T246517 WP_275071734.1 NZ_CP097896:992042-993376 [Pectobacterium actinidiae]
MPRIQQRLAIWMNGIQVGFWEKSRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQIWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVKYRPICDAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHERQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEDQKVLVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMDDI
IFRTPEVIERVSSLLPESFSPELAECVFDGMRQQCGRLQELHRK

Download         Length: 1335 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11313.11 Da        Isoelectric Point: 10.5325

>AT246517 WP_015848020.1 NZ_CP097896:991732-992037 [Pectobacterium actinidiae]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSGPRVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2R984

References