Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2503832..2505420 Replicon chromosome
Accession NZ_CP097726
Organism Escherichia coli strain MS1050

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M9O78_RS11940 Protein ID WP_001546825.1
Coordinates 2504098..2505420 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M9O78_RS11935 Protein ID WP_001296726.1
Coordinates 2503832..2504098 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O78_RS11935 (2503832) 2503832..2504098 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M9O78_RS11940 (2504098) 2504098..2505420 + 1323 WP_001546825.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
M9O78_RS11945 (2505818) 2505818..2506717 - 900 WP_001057776.1 LysR family transcriptional regulator -
M9O78_RS11950 (2506857) 2506857..2507165 + 309 WP_001221046.1 hypothetical protein -
M9O78_RS11955 (2507174) 2507174..2507863 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
M9O78_RS11960 (2507937) 2507937..2508884 + 948 WP_000854796.1 aldo/keto reductase -
M9O78_RS11965 (2508987) 2508987..2509142 + 156 WP_001322415.1 hypothetical protein -
M9O78_RS11970 (2509102) 2509102..2509521 + 420 WP_001322416.1 amidohydrolase family protein -
M9O78_RS11975 (2509511) 2509511..2509663 + 153 WP_001322417.1 amidohydrolase family protein -
M9O78_RS11980 (2509814) 2509814..2510386 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49331.00 Da        Isoelectric Point: 8.1369

>T246203 WP_001546825.1 NZ_CP097726:2504098-2505420 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHCRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT246203 WP_001296726.1 NZ_CP097726:2503832-2504098 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References