Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 995514..996168 Replicon chromosome
Accession NZ_CP097724
Organism Escherichia coli strain MS1494

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M9O75_RS04925 Protein ID WP_000244781.1
Coordinates 995761..996168 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M9O75_RS04920 Protein ID WP_000354046.1
Coordinates 995514..995780 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O75_RS04900 (991602) 991602..993035 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
M9O75_RS04905 (993080) 993080..993391 + 312 WP_001182948.1 N(4)-acetylcytidine aminohydrolase -
M9O75_RS04910 (993555) 993555..994214 + 660 WP_000250274.1 hemolysin III family protein -
M9O75_RS04915 (994291) 994291..995271 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
M9O75_RS04920 (995514) 995514..995780 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M9O75_RS04925 (995761) 995761..996168 + 408 WP_000244781.1 protein YgfX Toxin
M9O75_RS04930 (996208) 996208..996729 - 522 WP_001055874.1 flavodoxin FldB -
M9O75_RS04935 (996841) 996841..997737 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M9O75_RS04940 (997762) 997762..998472 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9O75_RS04945 (998478) 998478..1000211 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T246177 WP_000244781.1 NZ_CP097724:995761-996168 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT246177 WP_000354046.1 NZ_CP097724:995514-995780 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References