Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2567961..2569543 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J2BJD7
Locus tag M9O74_RS12570 Protein ID WP_001125469.1
Coordinates 2568227..2569543 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M9O74_RS12565 Protein ID WP_001296726.1
Coordinates 2567961..2568227 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS12550 (2563105) 2563105..2564058 + 954 WP_000154356.1 transcriptional regulator LsrR -
M9O74_RS12555 (2564137) 2564137..2565729 + 1593 WP_000113152.1 autoinducer-2 kinase -
M9O74_RS12560 (2565879) 2565879..2567768 + 1890 Protein_2459 autotransporter barrel domain-containing lipoprotein -
M9O74_RS12565 (2567961) 2567961..2568227 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M9O74_RS12570 (2568227) 2568227..2569543 + 1317 WP_001125469.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
M9O74_RS12575 (2569819) 2569819..2570085 + 267 Protein_2462 AraC family transcriptional regulator -
M9O74_RS12580 (2570519) 2570519..2571082 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
M9O74_RS12585 (2571444) 2571444..2571596 + 153 Protein_2464 hypothetical protein -
M9O74_RS12590 (2571739) 2571739..2572197 + 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -
M9O74_RS12595 (2572302) 2572302..2572865 + 564 Protein_2466 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2571739..2572197 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49275.91 Da        Isoelectric Point: 8.8783

>T246131 WP_001125469.1 NZ_CP097719:2568227-2569543 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Download         Length: 1317 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT246131 WP_001296726.1 NZ_CP097719:2567961-2568227 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2BJD7

Antitoxin

Source ID Structure

References