Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 303987..304618 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag M9O74_RS01395 Protein ID WP_001260301.1
Coordinates 303987..304262 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IZA1
Locus tag M9O74_RS01400 Protein ID WP_000593557.1
Coordinates 304259..304618 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS01380 (298991) 298991..300058 + 1068 WP_000361470.1 HlyD family secretion protein -
M9O74_RS01385 (300055) 300055..302790 + 2736 WP_032284871.1 ribosome-associated ATPase/putative transporter RbbA -
M9O74_RS01390 (302790) 302790..303914 + 1125 WP_001318088.1 ABC transporter permease -
M9O74_RS01395 (303987) 303987..304262 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
M9O74_RS01400 (304259) 304259..304618 + 360 WP_000593557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M9O74_RS01405 (304738) 304738..305139 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
M9O74_RS01410 (305145) 305145..305951 - 807 WP_000173650.1 nickel import ATP-binding protein NikE -
M9O74_RS01415 (305948) 305948..306712 - 765 WP_039025756.1 nickel import ATP-binding protein NikD -
M9O74_RS01420 (306712) 306712..307545 - 834 WP_260838138.1 nickel ABC transporter permease subunit NikC -
M9O74_RS01425 (307542) 307542..308486 - 945 WP_000947063.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T246119 WP_001260301.1 NZ_CP097719:303987-304262 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13389.28 Da        Isoelectric Point: 5.1987

>AT246119 WP_000593557.1 NZ_CP097719:304259-304618 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB L4IZA1

References