Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3255773..3256478 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M9O77_RS15650 Protein ID WP_000539521.1
Coordinates 3255773..3256159 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M9O77_RS15655 Protein ID WP_001280945.1
Coordinates 3256149..3256478 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS15630 (3251777) 3251777..3252403 + 627 WP_001295292.1 glutathione S-transferase GstB -
M9O77_RS15635 (3252400) 3252400..3253515 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
M9O77_RS15640 (3253626) 3253626..3254009 - 384 WP_000497137.1 biofilm formation regulator BssR -
M9O77_RS15645 (3254222) 3254222..3255547 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M9O77_RS15650 (3255773) 3255773..3256159 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9O77_RS15655 (3256149) 3256149..3256478 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M9O77_RS15660 (3256548) 3256548..3257876 - 1329 WP_022645414.1 GGDEF domain-containing protein -
M9O77_RS15665 (3257884) 3257884..3260232 - 2349 WP_022645413.1 EAL domain-containing protein -
M9O77_RS15670 (3260409) 3260409..3261320 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T246095 WP_000539521.1 NZ_CP097716:3255773-3256159 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT246095 WP_001280945.1 NZ_CP097716:3256149-3256478 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References