Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1549643..1550159 Replicon chromosome
Accession NZ_CP097654
Organism Klebsiella pneumoniae strain IR1272_1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M3T50_RS07505 Protein ID WP_002886902.1
Coordinates 1549643..1549927 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M3T50_RS07510 Protein ID WP_002886901.1
Coordinates 1549917..1550159 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T50_RS07480 (M3T50_07480) 1545127..1545390 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M3T50_RS07485 (M3T50_07485) 1545520..1545693 + 174 WP_002886906.1 hypothetical protein -
M3T50_RS07490 (M3T50_07490) 1545696..1546439 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M3T50_RS07495 (M3T50_07495) 1546796..1548934 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M3T50_RS07500 (M3T50_07500) 1549175..1549639 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3T50_RS07505 (M3T50_07505) 1549643..1549927 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3T50_RS07510 (M3T50_07510) 1549917..1550159 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3T50_RS07515 (M3T50_07515) 1550237..1552147 - 1911 WP_004152270.1 PRD domain-containing protein -
M3T50_RS07520 (M3T50_07520) 1552170..1553324 - 1155 WP_002886900.1 lactonase family protein -
M3T50_RS07525 (M3T50_07525) 1553390..1554082 - 693 WP_057172346.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245745 WP_002886902.1 NZ_CP097654:c1549927-1549643 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245745 WP_002886901.1 NZ_CP097654:c1550159-1549917 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References