Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 539743..540404 Replicon chromosome
Accession NZ_CP097635
Organism Aquincola tertiaricarbonis strain RN12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MW290_RS02425 Protein ID WP_250195732.1
Coordinates 539743..540174 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MW290_RS02430 Protein ID WP_250195733.1
Coordinates 540171..540404 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW290_RS02405 (MW290_02405) 534814..535650 + 837 WP_250195728.1 amidohydrolase family protein -
MW290_RS02410 (MW290_02410) 535712..536158 - 447 WP_250195729.1 hypothetical protein -
MW290_RS02415 (MW290_02415) 536307..539003 - 2697 WP_250195730.1 magnesium-translocating P-type ATPase -
MW290_RS02420 (MW290_02420) 539186..539626 - 441 WP_250195731.1 addiction module protein -
MW290_RS02425 (MW290_02425) 539743..540174 - 432 WP_250195732.1 VapC toxin family PIN domain ribonuclease Toxin
MW290_RS02430 (MW290_02430) 540171..540404 - 234 WP_250195733.1 CopG family transcriptional regulator Antitoxin
MW290_RS02435 (MW290_02435) 540662..540994 + 333 WP_250195734.1 helix-turn-helix domain-containing protein -
MW290_RS02440 (MW290_02440) 540987..542453 + 1467 WP_250195735.1 HipA domain-containing protein -
MW290_RS02445 (MW290_02445) 542491..543114 - 624 WP_250195736.1 glutathione S-transferase -
MW290_RS02450 (MW290_02450) 543123..544376 - 1254 WP_250195737.1 CaiB/BaiF CoA-transferase family protein -
MW290_RS02455 (MW290_02455) 544389..545165 - 777 WP_250195738.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 539743..548013 8270


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15268.68 Da        Isoelectric Point: 7.1712

>T245701 WP_250195732.1 NZ_CP097635:c540174-539743 [Aquincola tertiaricarbonis]
VIRYLLDVNVLIALIDPAHVQHDEVHEWFGKVGHKAFATCPITENGLLRIVGHPKYPNCPGPPSAVADALSAIRGLPGHA
FWPDSISLVQSDLVDPALLSSHSRVTDSYLLALARANKGKLATMDHKLATEVVAAGKTALALL

Download         Length: 432 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8366.57 Da        Isoelectric Point: 10.2948

>AT245701 WP_250195733.1 NZ_CP097635:c540404-540171 [Aquincola tertiaricarbonis]
VRTTLAIDDDILAAAKHLAEREHKSVGEVISSLARLGLSRSTRGSKTERNGIPLLPSRKAAVPVTLELVNQLRDEQP

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References