Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4730168..4730715 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name higB Uniprot ID I4ITK5
Locus tag M8120_RS23955 Protein ID WP_002803252.1
Coordinates 4730168..4730446 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8120_RS23960 Protein ID WP_190359849.1
Coordinates 4730446..4730715 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS23935 (M8120_23710) 4725330..4725707 + 378 WP_002778608.1 DUF433 domain-containing protein -
M8120_RS23940 (M8120_23715) 4725704..4726096 + 393 WP_002791850.1 hypothetical protein -
M8120_RS23945 (M8120_23720) 4726262..4727372 - 1111 Protein_4743 IS630 family transposase -
M8120_RS23950 (M8120_23725) 4728210..4730034 + 1825 Protein_4744 group II intron reverse transcriptase/maturase -
M8120_RS23955 (M8120_23730) 4730168..4730446 + 279 WP_002803252.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8120_RS23960 (M8120_23735) 4730446..4730715 + 270 WP_190359849.1 HigA family addiction module antitoxin Antitoxin
M8120_RS23965 (M8120_23740) 4730970..4731209 + 240 WP_242030267.1 hypothetical protein -
M8120_RS23970 (M8120_23745) 4731239..4731685 + 447 WP_103112768.1 hypothetical protein -
M8120_RS23975 (M8120_23750) 4731685..4732260 + 576 WP_265795537.1 hypothetical protein -
M8120_RS23980 (M8120_23755) 4732447..4733325 - 879 WP_190359848.1 UDP-N-acetylmuramate dehydrogenase -
M8120_RS23985 (M8120_23760) 4733741..4735168 - 1428 WP_190359847.1 UDP-N-acetylmuramate--L-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10369.79 Da        Isoelectric Point: 8.0988

>T245631 WP_002803252.1 NZ_CP097576:4730168-4730446 [Microcystis aeruginosa str. Chao 1910]
MIVSFKHRGLEQFFESGTTRGIQANHAKRIRLILARLSAATSPQDMNLPGLVLHELAGQRKGTWTVRVSGNWRITFTFDG
VDACDVDLEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9828.33 Da        Isoelectric Point: 5.6501

>AT245631 WP_190359849.1 NZ_CP097576:4730446-4730715 [Microcystis aeruginosa str. Chao 1910]
MKMHNPPHPGEVLKELCLEPLNLTVTEAAEALGVSRKTLSAILNGRAGISPEMAIRLGKAFDTSPESWLNQQMQYDLWQA
EQTIGNIKV

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857DB49

Antitoxin

Source ID Structure

References