Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 957684..958267 Replicon chromosome
Accession NZ_CP097430
Organism Escherichia coli strain C288

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M8Y68_RS04650 Protein ID WP_049253269.1
Coordinates 957932..958267 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1V2T5M9
Locus tag M8Y68_RS04645 Protein ID WP_000581941.1
Coordinates 957684..957932 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y68_RS04635 (954023) 954023..955324 + 1302 WP_023281448.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
M8Y68_RS04640 (955372) 955372..957606 + 2235 WP_000226815.1 GTP pyrophosphokinase -
M8Y68_RS04645 (957684) 957684..957932 + 249 WP_000581941.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
M8Y68_RS04650 (957932) 957932..958267 + 336 WP_049253269.1 endoribonuclease MazF Toxin
M8Y68_RS04655 (958338) 958338..959129 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
M8Y68_RS04660 (959357) 959357..960994 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
M8Y68_RS04665 (961082) 961082..962380 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12197.18 Da        Isoelectric Point: 8.7218

>T245470 WP_049253269.1 NZ_CP097430:957932-958267 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQARHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9385.76 Da        Isoelectric Point: 4.4665

>AT245470 WP_000581941.1 NZ_CP097430:957684-957932 [Escherichia coli]
MIHSSVKRWGNSPAVRIPTTLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2T5M9

References