Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4509472..4511060 Replicon chromosome
Accession NZ_CP097419
Organism Klebsiella pneumoniae strain K229

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag M8Y66_RS22045 Protein ID WP_004199851.1
Coordinates 4509738..4511060 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M8Y66_RS22040 Protein ID WP_002904790.1
Coordinates 4509472..4509738 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y66_RS22015 (M8Y66_22015) 4504622..4505545 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
M8Y66_RS22020 (M8Y66_22020) 4505526..4506680 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M8Y66_RS22025 (M8Y66_22025) 4507026..4508405 + 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
M8Y66_RS22030 (M8Y66_22030) 4508383..4508883 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M8Y66_RS22035 (M8Y66_22035) 4508880..4509206 + 327 WP_002904788.1 hydroxyisourate hydrolase -
M8Y66_RS22040 (M8Y66_22040) 4509472..4509738 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M8Y66_RS22045 (M8Y66_22045) 4509738..4511060 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
M8Y66_RS22050 (M8Y66_22050) 4511077..4512369 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M8Y66_RS22055 (M8Y66_22055) 4512502..4513506 - 1005 WP_004199852.1 fimbrial protein -
M8Y66_RS22060 (M8Y66_22060) 4513494..4515995 - 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T245417 WP_004199851.1 NZ_CP097419:4509738-4511060 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT245417 WP_002904790.1 NZ_CP097419:4509472-4509738 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References