Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 536123..536759 Replicon chromosome
Accession NZ_CP097374
Organism Bacillus safensis strain AHB11

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag M5E03_RS02595 Protein ID WP_024425388.1
Coordinates 536409..536759 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag M5E03_RS02590 Protein ID WP_003214273.1
Coordinates 536123..536404 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5E03_RS02570 (M5E03_02570) 532277..532882 - 606 WP_041116754.1 rhomboid family intramembrane serine protease -
M5E03_RS02575 (M5E03_02575) 532977..533342 + 366 WP_061110630.1 holo-ACP synthase -
M5E03_RS02580 (M5E03_02580) 533503..534519 + 1017 WP_098677666.1 outer membrane lipoprotein-sorting protein -
M5E03_RS02585 (M5E03_02585) 534647..535828 + 1182 WP_034283949.1 alanine racemase -
M5E03_RS02590 (M5E03_02590) 536123..536404 + 282 WP_003214273.1 hypothetical protein Antitoxin
M5E03_RS02595 (M5E03_02595) 536409..536759 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
M5E03_RS02600 (M5E03_02600) 536875..537705 + 831 WP_034283948.1 RsbT co-antagonist protein RsbRA -
M5E03_RS02605 (M5E03_02605) 537710..538078 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
M5E03_RS02610 (M5E03_02610) 538081..538482 + 402 WP_024427376.1 anti-sigma regulatory factor -
M5E03_RS02615 (M5E03_02615) 538493..539500 + 1008 WP_024427377.1 PP2C family protein-serine/threonine phosphatase -
M5E03_RS02620 (M5E03_02620) 539560..539889 + 330 WP_024425392.1 anti-sigma factor antagonist -
M5E03_RS02625 (M5E03_02625) 539886..540374 + 489 WP_034283945.1 anti-sigma B factor RsbW -
M5E03_RS02630 (M5E03_02630) 540340..541128 + 789 WP_048240336.1 RNA polymerase sigma factor SigB -
M5E03_RS02635 (M5E03_02635) 541128..541727 + 600 WP_176967302.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T245337 WP_024425388.1 NZ_CP097374:536409-536759 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT245337 WP_003214273.1 NZ_CP097374:536123-536404 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References