Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1761351..1762001 Replicon chromosome
Accession NZ_CP097335
Organism Mannheimia haemolytica strain NCTC 10208

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3704_RS08250 Protein ID WP_154703935.1
Coordinates 1761351..1761740 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D2Q6P1
Locus tag M3704_RS08255 Protein ID WP_006251766.1
Coordinates 1761741..1762001 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3704_RS08200 (M3704_08200) 1756697..1757506 - 810 WP_154703939.1 metal ABC transporter permease -
M3704_RS08205 (M3704_08205) 1757499..1758359 - 861 WP_154703938.1 metal ABC transporter permease -
M3704_RS08210 (M3704_08210) 1758433..1759218 - 786 WP_154703937.1 GDP-L-fucose synthase -
M3704_RS08245 (M3704_08245) 1760083..1761321 - 1239 WP_154703936.1 peptidase T -
M3704_RS08250 (M3704_08250) 1761351..1761740 - 390 WP_154703935.1 type II toxin-antitoxin system VapC family toxin Toxin
M3704_RS08255 (M3704_08255) 1761741..1762001 - 261 WP_006251766.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M3704_RS08260 (M3704_08260) 1762112..1762324 - 213 WP_126302498.1 BrnA antitoxin family protein -
M3704_RS08265 (M3704_08265) 1762471..1762860 - 390 WP_172595359.1 helix-turn-helix transcriptional regulator -
M3704_RS08270 (M3704_08270) 1762963..1763220 + 258 WP_126302500.1 hypothetical protein -
M3704_RS08275 (M3704_08275) 1763234..1763407 + 174 WP_126302501.1 excalibur calcium-binding domain-containing protein -
M3704_RS08280 (M3704_08280) 1763462..1766995 - 3534 WP_154703934.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14605.86 Da        Isoelectric Point: 7.1041

>T245194 WP_154703935.1 NZ_CP097335:c1761740-1761351 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSATAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.50 Da        Isoelectric Point: 4.6909

>AT245194 WP_006251766.1 NZ_CP097335:c1762001-1761741 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1D2Q6P1

References