Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3813484..3814058 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5I08_RS19875 Protein ID WP_219069929.1
Coordinates 3813678..3814058 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M5I08_RS19870 Protein ID WP_219069927.1
Coordinates 3813484..3813681 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS19845 (M5I08_19845) 3808966..3809397 - 432 WP_219069917.1 Hsp20/alpha crystallin family protein -
M5I08_RS19850 (M5I08_19850) 3809602..3810501 + 900 WP_219069919.1 universal stress protein -
M5I08_RS19855 (M5I08_19855) 3810550..3811734 + 1185 WP_219069921.1 site-2 protease family protein -
M5I08_RS19860 (M5I08_19860) 3811731..3812543 + 813 WP_219069923.1 universal stress protein -
M5I08_RS19865 (M5I08_19865) 3812688..3813119 - 432 WP_249762923.1 hypothetical protein -
M5I08_RS19870 (M5I08_19870) 3813484..3813681 + 198 WP_219069927.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M5I08_RS19875 (M5I08_19875) 3813678..3814058 + 381 WP_219069929.1 type II toxin-antitoxin system VapC family toxin Toxin
M5I08_RS19880 (M5I08_19880) 3814167..3815135 - 969 Protein_3947 proline dehydrogenase family protein -
M5I08_RS19885 (M5I08_19885) 3815132..3816763 - 1632 WP_219069932.1 L-glutamate gamma-semialdehyde dehydrogenase -
M5I08_RS19890 (M5I08_19890) 3816847..3818427 + 1581 WP_219069934.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13643.65 Da        Isoelectric Point: 6.9167

>T245137 WP_219069929.1 NZ_CP097320:3813678-3814058 [Candidatus Mycobacterium methanotrophicum]
VILVDTSVWIDHLHKTDPQLVALLGADEVGSHAHVIEELGLGSIRRRAVVLELLGNLHQFPVLSHAEVMALVDSRRLFGR
GLSAVDAHLLGSVSVTGGARLWTRDKRLISACRHIGASYVDDDGAR

Download         Length: 381 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7076.11 Da        Isoelectric Point: 11.6141

>AT245137 WP_219069927.1 NZ_CP097320:3813484-3813681 [Candidatus Mycobacterium methanotrophicum]
MRTTVTIDDELLARASELTGITEKSALLRDGLVTLIRVESARRLAALGGSDKRASAAPRRRRSPE

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References