Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2917311..2917999 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5I08_RS15125 Protein ID WP_219070181.1
Coordinates 2917311..2917748 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M5I08_RS15130 Protein ID WP_219070183.1
Coordinates 2917745..2917999 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS15105 (M5I08_15105) 2912567..2913715 + 1149 WP_219070177.1 LLM class flavin-dependent oxidoreductase -
M5I08_RS15110 (M5I08_15110) 2914043..2914291 + 249 Protein_2991 DUF6444 domain-containing protein -
M5I08_RS15115 (M5I08_15115) 2914566..2916425 - 1860 WP_249762807.1 hypothetical protein -
M5I08_RS15120 (M5I08_15120) 2916445..2917185 - 741 WP_249762808.1 nitroreductase family protein -
M5I08_RS15125 (M5I08_15125) 2917311..2917748 - 438 WP_219070181.1 type II toxin-antitoxin system VapC family toxin Toxin
M5I08_RS15130 (M5I08_15130) 2917745..2917999 - 255 WP_219070183.1 antitoxin Antitoxin
M5I08_RS15135 (M5I08_15135) 2918073..2918573 - 501 WP_219070185.1 DUF2505 domain-containing protein -
M5I08_RS15140 (M5I08_15140) 2918588..2919268 - 681 WP_219070187.1 flavodoxin family protein -
M5I08_RS15145 (M5I08_15145) 2919366..2920199 + 834 WP_219070189.1 class I SAM-dependent methyltransferase -
M5I08_RS15150 (M5I08_15150) 2920338..2920716 + 379 Protein_2999 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15395.41 Da        Isoelectric Point: 6.4832

>T245133 WP_219070181.1 NZ_CP097320:c2917748-2917311 [Candidatus Mycobacterium methanotrophicum]
MRIVDANVLLYAVNTAAGHHEASRRWLDGALSGRDTVGLAWVPLLAFVQLTTRHGLFPSPLTADAAMAQVLDWCNAPASV
IVSPTARHGDVLSGLLSQVGAGGNLVNDAHLAALAIEHRARIVSYDSDFGRFDGVRWETPGSLSN

Download         Length: 438 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9427.68 Da        Isoelectric Point: 11.4945

>AT245133 WP_219070183.1 NZ_CP097320:c2917999-2917745 [Candidatus Mycobacterium methanotrophicum]
VRTTVTLDDDTLVVVRQLMRQRNVSFKQALNDAIRQGAQRRPAGAVFQTRTADLGVPSVNLDRALQIAGELEDEDLIRRQ
RRGA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References