Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2551035..2551591 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M5I08_RS13340 Protein ID WP_219067761.1
Coordinates 2551280..2551591 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M5I08_RS13335 Protein ID WP_249763359.1
Coordinates 2551035..2551280 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS13315 (M5I08_13315) 2546120..2546842 + 723 WP_219067756.1 cobalt-precorrin-6A reductase -
M5I08_RS13320 (M5I08_13320) 2547174..2548646 - 1473 WP_219067757.1 precorrin-2 C(20)-methyltransferase -
M5I08_RS13325 (M5I08_13325) 2548643..2549269 - 627 WP_219067758.1 precorrin-8X methylmutase -
M5I08_RS13330 (M5I08_13330) 2549279..2550376 - 1098 WP_219067759.1 precorrin-3B synthase -
M5I08_RS13335 (M5I08_13335) 2551035..2551280 + 246 WP_249763359.1 YlcI/YnfO family protein Antitoxin
M5I08_RS13340 (M5I08_13340) 2551280..2551591 + 312 WP_219067761.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M5I08_RS13345 (M5I08_13345) 2551753..2552499 - 747 WP_219067762.1 hemerythrin domain-containing protein -
M5I08_RS13350 (M5I08_13350) 2552798..2553976 + 1179 WP_219067763.1 PPE family protein -
M5I08_RS13355 (M5I08_13355) 2554101..2555360 + 1260 WP_219067764.1 PPE family protein -
M5I08_RS13360 (M5I08_13360) 2555378..2555686 + 309 WP_219067765.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11017.75 Da        Isoelectric Point: 5.5815

>T245129 WP_219067761.1 NZ_CP097320:2551280-2551591 [Candidatus Mycobacterium methanotrophicum]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVGPITTTVRGLATEVPVGIVNGLNQPSVVSCDNIQTIPVSDLGRQIGYL
LASQEPALADAIGNAFDLDWVVS

Download         Length: 312 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8982.14 Da        Isoelectric Point: 5.1409

>AT245129 WP_249763359.1 NZ_CP097320:2551035-2551280 [Candidatus Mycobacterium methanotrophicum]
IYEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVVRALERERRRRLAERDAEILAASLSAPSDLDALAGRSARTVLDI
D

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References