Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411583..3412203 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag M3N94_RS16795 Protein ID WP_001280991.1
Coordinates 3411985..3412203 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag M3N94_RS16790 Protein ID WP_000344807.1
Coordinates 3411583..3411957 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N94_RS16780 (3406722) 3406722..3407915 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M3N94_RS16785 (3407938) 3407938..3411087 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
M3N94_RS16790 (3411583) 3411583..3411957 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
M3N94_RS16795 (3411985) 3411985..3412203 + 219 WP_001280991.1 HHA domain-containing protein Toxin
M3N94_RS16800 (3412382) 3412382..3412933 + 552 WP_001278793.1 maltose O-acetyltransferase -
M3N94_RS16805 (3413051) 3413051..3413521 + 471 WP_000136183.1 YlaC family protein -
M3N94_RS16810 (3413577) 3413577..3413717 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
M3N94_RS16815 (3413723) 3413723..3413983 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
M3N94_RS16820 (3414208) 3414208..3415758 + 1551 WP_000213140.1 EAL domain-containing protein -
M3N94_RS16830 (3415989) 3415989..3416378 + 390 WP_000961287.1 MGMT family protein -
M3N94_RS16835 (3416411) 3416411..3416980 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T245082 WP_001280991.1 NZ_CP097262:3411985-3412203 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT245082 WP_000344807.1 NZ_CP097262:3411583-3411957 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References