Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2299438..2300416 Replicon chromosome
Accession NZ_CP097257
Organism Bacillus thuringiensis strain Bt Gxmzu777-1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag M3Y14_RS11890 Protein ID WP_264540821.1
Coordinates 2299438..2300178 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag M3Y14_RS11895 Protein ID WP_000588712.1
Coordinates 2300291..2300416 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3Y14_RS11870 (M3Y14_11820) 2295152..2296072 - 921 WP_264540819.1 type II CAAX endopeptidase family protein -
M3Y14_RS11875 (M3Y14_11825) 2296660..2297748 - 1089 Protein_2330 thiamine pyrophosphate-binding protein -
M3Y14_RS11880 (M3Y14_11830) 2297866..2298348 + 483 WP_219918435.1 MarR family winged helix-turn-helix transcriptional regulator -
M3Y14_RS11885 (M3Y14_11835) 2298516..2299253 + 738 WP_264540820.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
M3Y14_RS11890 (M3Y14_11840) 2299438..2300178 + 741 WP_264540821.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M3Y14_RS11895 (M3Y14_11845) 2300291..2300416 + 126 WP_000588712.1 hypothetical protein Antitoxin
M3Y14_RS11900 (M3Y14_11850) 2300492..2300668 + 177 WP_000852629.1 stage II sporulation protein SB -
M3Y14_RS11905 (M3Y14_11855) 2300688..2301077 - 390 WP_264540822.1 YxeA family protein -
M3Y14_RS11910 (M3Y14_11860) 2301289..2302758 + 1470 WP_264540823.1 beta-Ala-His dipeptidase -
M3Y14_RS11915 (M3Y14_11865) 2302781..2302939 - 159 WP_258237061.1 hypothetical protein -
M3Y14_RS11920 (M3Y14_11870) 2303344..2303820 - 477 WP_219918451.1 DUF5065 family protein -
M3Y14_RS11925 (M3Y14_11875) 2304274..2304933 + 660 WP_264540824.1 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28450.13 Da        Isoelectric Point: 8.2672

>T245066 WP_264540821.1 NZ_CP097257:2299438-2300178 [Bacillus thuringiensis]
MTISNIRIGLFILVIAFVVLVFFYWRNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNSFLDSYGEKIGAK
IVVFEAAKELNTNFRGIRSQFSTIVPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLAIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT245066 WP_000588712.1 NZ_CP097257:2300291-2300416 [Bacillus thuringiensis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References