Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5061014..5061584 Replicon chromosome
Accession NZ_CP097252
Organism Mesorhizobium opportunistum strain WSM1558

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M5D98_RS24695 Protein ID WP_224686661.1
Coordinates 5061014..5061175 (+) Length 54 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M5D98_RS24700 Protein ID WP_224686660.1
Coordinates 5061186..5061584 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D98_RS24665 (M5D98_24665) 5056297..5057577 - 1281 WP_023764113.1 O-acetylhomoserine aminocarboxypropyltransferase -
M5D98_RS24670 (M5D98_24670) 5057736..5058257 - 522 WP_224686666.1 CoA-binding protein -
M5D98_RS24675 (M5D98_24675) 5058254..5059036 - 783 WP_224686665.1 AAA family ATPase -
M5D98_RS24680 (M5D98_24680) 5059064..5059486 - 423 WP_224686664.1 VOC family protein -
M5D98_RS24685 (M5D98_24685) 5059500..5060321 - 822 WP_224686663.1 enoyl-CoA hydratase -
M5D98_RS24690 (M5D98_24690) 5060491..5060940 + 450 WP_224686662.1 PaaI family thioesterase -
M5D98_RS24695 (M5D98_24695) 5061014..5061175 + 162 WP_224686661.1 type II toxin-antitoxin system HicA family toxin Toxin
M5D98_RS24700 (M5D98_24700) 5061186..5061584 + 399 WP_224686660.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5D98_RS24705 (M5D98_24705) 5061849..5062313 + 465 WP_010915638.1 50S ribosomal protein L13 -
M5D98_RS24710 (M5D98_24710) 5062315..5062797 + 483 WP_023764104.1 30S ribosomal protein S9 -
M5D98_RS24715 (M5D98_24715) 5063066..5064121 - 1056 WP_224686659.1 glycerophosphodiester phosphodiesterase family protein -
M5D98_RS24720 (M5D98_24720) 5064219..5065427 - 1209 WP_224686658.1 acyltransferase -
M5D98_RS24725 (M5D98_24725) 5065552..5066559 + 1008 WP_224686657.1 agmatinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-50)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6003.07 Da        Isoelectric Point: 11.3260

>T245044 WP_224686661.1 NZ_CP097252:5061014-5061175 [Mesorhizobium opportunistum]
MKRLKEDGFELISIRGSHHKFRKGEIVLIVPHPEKDLPTGTARAIAKQAGRIR

Download         Length: 162 bp

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14220.04 Da        Isoelectric Point: 4.4101

>AT245044 WP_224686660.1 NZ_CP097252:5061186-5061584 [Mesorhizobium opportunistum]
MKNYFALVDKDPDSAFGIRFPDIPGCFSAADAAEDIVPNAVEALQLWAEDMPVPEPSSHEAIVALPDIRNALAEGGYLVS
VPLIDNDSAVVRANVTFERGVLRAIDAAARERGITRSAFLSSAARREIEAKH

Download         Length: 399 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References