Detailed information of TA system TA244926

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 46372..46793
• Replicon: plasmid unnamed1
• Accession: NZ_CP097214
• Organism: Escherichia coli strain BE311

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: M3O69_RS23655
• Protein ID: WP_096937776.1
• Coordinates: 46668..46793 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	46372..46570 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M3O69_RS23620 (41475)	41475..41984	-	510	WP_071532140.1	hypothetical protein	-
M3O69_RS23625 (42302)	42302..42841	+	540	WP_000290801.1	single-stranded DNA-binding protein	-
M3O69_RS23630 (42898)	42898..43131	+	234	WP_000005990.1	DUF905 family protein	-
M3O69_RS23635 (43197)	43197..45155	+	1959	WP_000117171.1	ParB/RepB/Spo0J family partition protein	-
M3O69_RS23640 (45210)	45210..45644	+	435	WP_000845928.1	conjugation system SOS inhibitor PsiB	-
M3O69_RS23645 (45641)	45641..46403	+	763	Protein_57	plasmid SOS inhibition protein A	-
- (46372)	46372..46570	+	199	NuclAT_0	-	Antitoxin
- (46372)	46372..46570	+	199	NuclAT_0	-	Antitoxin
- (46372)	46372..46570	+	199	NuclAT_0	-	Antitoxin
- (46372)	46372..46570	+	199	NuclAT_0	-	Antitoxin
M3O69_RS23650 (46577)	46577..46726	+	150	Protein_58	DUF5431 family protein	-
M3O69_RS23655 (46668)	46668..46793	+	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
M3O69_RS23660 (47094)	47094..47371	-	278	Protein_60	hypothetical protein	-
M3O69_RS23665 (47688)	47688..47975	+	288	WP_000107542.1	hypothetical protein	-
M3O69_RS23670 (48094)	48094..48915	+	822	WP_001234475.1	DUF932 domain-containing protein	-
M3O69_RS23675 (49211)	49211..49801	-	591	WP_001375132.1	transglycosylase SLT domain-containing protein	-
M3O69_RS23680 (50153)	50153..50536	+	384	WP_001063020.1	conjugal transfer relaxosome DNA-binding protein TraM	-
M3O69_RS23685 (50727)	50727..51374	+	648	WP_000332520.1	conjugal transfer transcriptional regulator TraJ	-
M3O69_RS23690 (51510)	51510..51725	+	216	WP_001352842.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	paa	1..113297	113297

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T244926 WP_096937776.1 NZ_CP097214:46668-46793 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 199 bp

>AT244926 NZ_CP097214:46372-46570 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Structures

Antitoxin