Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2265974..2267643 Replicon chromosome
Accession NZ_CP097127
Organism Conexibacter sp. S30A1

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag M3M54_RS11060 Protein ID WP_249019105.1
Coordinates 2265974..2267284 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag M3M54_RS11065 Protein ID WP_249019106.1
Coordinates 2267281..2267643 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M54_RS11035 2261194..2261847 - 654 WP_249019100.1 response regulator transcription factor -
M3M54_RS11040 2261844..2263139 - 1296 WP_249019101.1 hypothetical protein -
M3M54_RS11045 2263136..2264194 - 1059 WP_249019102.1 PspC domain-containing protein -
M3M54_RS11050 2264191..2264724 - 534 WP_249019103.1 hypothetical protein -
M3M54_RS11055 2265148..2265588 - 441 WP_249019104.1 DCC1-like thiol-disulfide oxidoreductase family protein -
M3M54_RS11060 2265974..2267284 - 1311 WP_249019105.1 type II toxin-antitoxin system HipA family toxin Toxin
M3M54_RS11065 2267281..2267643 - 363 WP_249019106.1 helix-turn-helix transcriptional regulator Antitoxin
M3M54_RS11070 2268254..2269489 - 1236 WP_249019107.1 IS4 family transposase -
M3M54_RS11075 2269556..2271328 - 1773 WP_249019108.1 IS1634 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 47788.26 Da        Isoelectric Point: 7.0209

>T244812 WP_249019105.1 NZ_CP097127:c2267284-2265974 [Conexibacter sp. S30A1]
VTTAAVTLWGREIGAVSVAAAGAVPVFQYRPEFVRSGVELSPVHMPLRTTPYSFAALNRDEAFHGLPGLLADALPDRWGQ
TLINVWLDAQGRSPDSFDVVERLCYIGTRGIGALEFQPAISTQAPHGTDLEVGKLVELATAVLEQRAAFVASLASDPDEQ
ELSAILTLGTSAGGARPKAIIAFNEQTGQVRSGQLDVGPGFQHWLLKFDGVGRAGDHGLHDPQGWGAIEFAYWRMARAAG
IETPESRLLPENGRRHFMTRRFDRPDAGGKLHVQTVGALEHVSYNIPGIYSYERAFLLVRKLGLGVPEAEALFRRMVFNI
VARNQDDHVKNISFIMGRDGFWQLAPAYDLTFAFAPGNQWLQAHQMTANGKRDGFTVADLNAVGKAAGLKRGRPQHILAE
VTDVVAEWPRIADELRISESMRDHIRGAHRLKLPQN

Download         Length: 1311 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13369.24 Da        Isoelectric Point: 7.2091

>AT244812 WP_249019106.1 NZ_CP097127:c2267643-2267281 [Conexibacter sp. S30A1]
MLSFVELTDAAILRELGRRLEAHRLERNLTQIELGDLAGLGRSTIQKIEGGGSVQTASLVKVLRALDLLTAVDAAIPDRV
VLPVMELDRIRRTRRRARHRSTEGGAQQPSEETWTWGDES

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References