Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4819583..4821264 Replicon chromosome
Accession NZ_CP097079
Organism Klebsiella pneumoniae strain KP131

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag M3I83_RS23315 Protein ID WP_004146663.1
Coordinates 4819583..4820500 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M3I83_RS23320 Protein ID WP_004177809.1
Coordinates 4820506..4821264 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3I83_RS23295 (4814889) 4814889..4816409 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
M3I83_RS23300 (4816406) 4816406..4817404 + 999 WP_002885172.1 ribose ABC transporter permease -
M3I83_RS23305 (4817435) 4817435..4818376 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M3I83_RS23310 (4818451) 4818451..4819458 + 1008 WP_269897269.1 carbohydrate kinase family protein -
M3I83_RS23315 (4819583) 4819583..4820500 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M3I83_RS23320 (4820506) 4820506..4821264 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M3I83_RS23325 (4821350) 4821350..4822078 - 729 WP_004177810.1 response regulator transcription factor -
M3I83_RS23330 (4822351) 4822351..4824498 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
M3I83_RS23335 (4824495) 4824495..4824638 - 144 WP_022631365.1 hypothetical protein -
M3I83_RS23340 (4824844) 4824844..4825530 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T244743 WP_004146663.1 NZ_CP097079:c4820500-4819583 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT244743 WP_004177809.1 NZ_CP097079:c4821264-4820506 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2XCI1

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References