Detailed information of TA system TA024463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2589572..2590272
• Replicon: chromosome
• Accession: NC_013595
• Organism: Streptosporangium roseum DSM 43021

Toxin (Protein)

• Gene name: higB
• Uniprot ID: D2B1A8
• Locus tag: SROS_RS11600
• Protein ID: WP_012889118.1
• Coordinates: 2589572..2589943 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SROS_RS11605
• Protein ID: WP_012889119.1
• Coordinates: 2589940..2590272 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SROS_RS11585	2585113..2585694	+	582	WP_148269024.1	hypothetical protein	-
SROS_RS11590	2585742..2586296	+	555	WP_012889116.1	hypothetical protein	-
SROS_RS11595	2586335..2589211	-	2877	WP_012889117.1	hypothetical protein	-
SROS_RS11600	2589572..2589943	+	372	WP_012889118.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SROS_RS11605	2589940..2590272	+	333	WP_012889119.1	helix-turn-helix transcriptional regulator	Antitoxin
SROS_RS11610	2590543..2590917	+	375	WP_012889120.1	hypothetical protein	-
SROS_RS11615	2591252..2591620	+	369	WP_043651835.1	hypothetical protein	-
SROS_RS11630	2592590..2593903	+	1314	WP_012889122.1	SDR family oxidoreductase	-
SROS_RS11635	2593897..2595003	+	1107	WP_012889123.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-97)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 14037.77 Da
• Isoelectric Point: 4.4321

>T24463 WP_012889118.1 NC_013595:2589572-2589943 [Streptosporangium roseum DSM 43021]
MSWEISLHPEVEAWYLEICVSDSETADLIKDAIDQLAEEGPTARRPLVDRLQGSRFHNMKELRPPSSGSSEIRIIFAFDP
AREAIFLVAGDKAGNWEGWYRQAIPLADERFEEHLIALKEEGR

Nucleotide

• Length: 372 bp

>T24463 NC_013595:2589572-2589943 [Streptosporangium roseum DSM 43021]
ATGAGCTGGGAGATCAGTCTGCATCCCGAGGTGGAAGCGTGGTATCTGGAGATCTGCGTGAGTGATTCCGAGACGGCAGA
TCTGATCAAGGACGCCATCGACCAACTCGCGGAGGAGGGGCCGACGGCTCGGCGGCCGTTGGTCGACCGGCTGCAGGGGA
GCCGCTTTCACAACATGAAGGAGCTGCGGCCTCCCTCATCGGGGAGCAGTGAAATTCGGATCATCTTCGCGTTCGACCCG
GCTCGGGAAGCCATCTTCCTGGTGGCCGGCGACAAAGCCGGCAACTGGGAAGGCTGGTACCGCCAGGCGATCCCATTGGC
CGACGAACGGTTCGAAGAGCACTTGATCGCGTTGAAGGAGGAGGGGCGATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 11851.44 Da
• Isoelectric Point: 10.0908

>AT24463 WP_012889119.1 NC_013595:2589940-2590272 [Streptosporangium roseum DSM 43021]
MSGGYSKWTDVKAKARALDPRSDAERAVGQEAARQRREAYVRGYQLAEMRKAAGITQVELAEALGVTQARISKIENGEVS
GIDVVRAYVTALGGTVDLVATLGNRTWKVA

Nucleotide

• Length: 333 bp

>AT24463 NC_013595:2589940-2590272 [Streptosporangium roseum DSM 43021]
ATGAGCGGCGGATACTCCAAGTGGACCGACGTCAAGGCGAAGGCGCGGGCGCTCGACCCGCGTTCGGATGCCGAGCGGGC
GGTCGGGCAAGAGGCTGCCCGTCAGCGCCGGGAGGCGTACGTGCGCGGCTATCAGCTCGCCGAGATGCGCAAGGCGGCCG
GCATCACCCAGGTGGAACTCGCCGAGGCTCTTGGGGTGACGCAGGCGCGAATCTCCAAGATCGAGAACGGCGAGGTGTCC
GGCATCGATGTCGTACGTGCCTATGTCACGGCGCTCGGAGGAACGGTTGATCTCGTCGCGACCCTGGGCAATCGAACCTG
GAAAGTCGCCTGA

Structures

Toxin

• AlphaFold DB: A0A1I3SH42