Detailed information of TA system TA244542

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2505041..2505302
• Replicon: chromosome
• Accession: NZ_CP097042
• Organism: Enterococcus faecalis strain AT34

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2910_RS11845
• Protein ID: WP_162780856.1
• Coordinates: 2505201..2505302 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2505041..2505247 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2910_RS11820 (2500696)	2500696..2501649	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
M2910_RS11825 (2501688)	2501688..2502443	-	756	WP_002375575.1	ATP-binding cassette domain-containing protein	-
M2910_RS11830 (2502440)	2502440..2503405	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
M2910_RS11835 (2503402)	2503402..2504349	-	948	WP_002375573.1	iron chelate uptake ABC transporter family permease subunit	-
M2910_RS11840 (2504533)	2504533..2504985	+	453	WP_002375572.1	YueI family protein	-
- (2505041)	2505041..2505247	+	207	NuclAT_7	-	Antitoxin
- (2505078)	2505078..2505264	+	187	NuclAT_9	-	-
M2910_RS11845 (2505201)	2505201..2505302	-	102	WP_162780856.1	putative holin-like toxin	Toxin
M2910_RS11850 (2505494)	2505494..2507764	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2910_RS11855 (2507935)	2507935..2508435	+	501	WP_002395960.1	cysteine hydrolase family protein	-
M2910_RS11860 (2509234)	2509234..2510130	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T244542 WP_162780856.1 NZ_CP097042:c2505302-2505201 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 207 bp

>AT244542 NZ_CP097042:2505041-2505247 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATGAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGG
TTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin