Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1725476..1726518 | Replicon | chromosome |
| Accession | NC_013510 | ||
| Organism | Thermomonospora curvata DSM 43183 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | TCUR_RS07400 | Protein ID | WP_012851866.1 |
| Coordinates | 1725934..1726518 (+) | Length | 195 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | D1AAS1 |
| Locus tag | TCUR_RS07395 | Protein ID | WP_012851865.1 |
| Coordinates | 1725476..1725931 (+) | Length | 152 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TCUR_RS07385 | 1722929..1724002 | - | 1074 | WP_052305446.1 | hypothetical protein | - |
| TCUR_RS25500 | 1724001..1725288 | + | 1288 | Protein_1480 | PD-(D/E)XK nuclease family protein | - |
| TCUR_RS07395 | 1725476..1725931 | + | 456 | WP_012851865.1 | excisionase family DNA-binding protein | Antitoxin |
| TCUR_RS07400 | 1725934..1726518 | + | 585 | WP_012851866.1 | PIN domain-containing protein | Toxin |
| TCUR_RS26350 | 1726680..1726988 | - | 309 | WP_148232951.1 | hypothetical protein | - |
| TCUR_RS07410 | 1727063..1727365 | - | 303 | WP_148232952.1 | hypothetical protein | - |
| TCUR_RS07415 | 1727507..1727779 | - | 273 | WP_012851867.1 | hypothetical protein | - |
| TCUR_RS07420 | 1728283..1728582 | + | 300 | WP_012851869.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| TCUR_RS07435 | 1729500..1730222 | - | 723 | WP_012851870.1 | TetR/AcrR family transcriptional regulator | - |
| TCUR_RS07440 | 1730439..1730810 | + | 372 | WP_012851871.1 | DoxX family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1711029..1728582 | 17553 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 195 a.a. Molecular weight: 21685.83 Da Isoelectric Point: 4.5097
>T24441 WP_012851866.1 NC_013510:1725934-1726518 [Thermomonospora curvata DSM 43183]
MAFVVVYDACVLYGNTQRDLLIRIAQSGLVQAKWTNAILDELQKNLTAGRPDIPVEKLIRLRTLMNRAVPDALVEGYEPL
IEALKLPDLEDRHVLAAAIKAQAQVIVTSNLRDFPADMLEPWNVEAKSPDDFVLDQIDFDDRVVWACVQQIVDSRNNPPE
TVEDVLDALERAGLVESVAALRTRSHRGFSTRGL
MAFVVVYDACVLYGNTQRDLLIRIAQSGLVQAKWTNAILDELQKNLTAGRPDIPVEKLIRLRTLMNRAVPDALVEGYEPL
IEALKLPDLEDRHVLAAAIKAQAQVIVTSNLRDFPADMLEPWNVEAKSPDDFVLDQIDFDDRVVWACVQQIVDSRNNPPE
TVEDVLDALERAGLVESVAALRTRSHRGFSTRGL
Download Length: 585 bp
>T24441 NC_013510:1725934-1726518 [Thermomonospora curvata DSM 43183]
ATGGCGTTCGTGGTGGTCTACGATGCCTGCGTTCTGTACGGCAACACGCAACGCGACCTGCTGATCCGCATTGCCCAGTC
GGGGCTGGTCCAGGCCAAGTGGACGAACGCCATTCTCGATGAGCTGCAAAAGAACCTGACCGCCGGCCGTCCGGACATTC
CTGTGGAGAAACTGATCAGGTTGCGCACCCTGATGAACCGGGCGGTCCCCGATGCCCTCGTCGAGGGTTACGAACCGCTC
ATCGAGGCGCTGAAACTCCCCGATCTCGAAGACCGGCATGTCCTGGCCGCCGCGATCAAGGCTCAGGCCCAGGTGATCGT
CACCTCGAACCTTCGAGATTTCCCGGCCGACATGCTGGAACCCTGGAACGTGGAGGCCAAAAGCCCCGACGACTTCGTCC
TCGATCAGATCGACTTCGACGACCGGGTCGTGTGGGCGTGCGTCCAGCAGATCGTCGACTCACGGAACAACCCGCCTGAA
ACGGTCGAGGATGTGCTGGACGCTCTCGAACGCGCCGGCCTGGTCGAGTCCGTCGCGGCCTTGCGGACACGAAGTCATCG
GGGTTTTTCAACACGCGGCCTTTGA
ATGGCGTTCGTGGTGGTCTACGATGCCTGCGTTCTGTACGGCAACACGCAACGCGACCTGCTGATCCGCATTGCCCAGTC
GGGGCTGGTCCAGGCCAAGTGGACGAACGCCATTCTCGATGAGCTGCAAAAGAACCTGACCGCCGGCCGTCCGGACATTC
CTGTGGAGAAACTGATCAGGTTGCGCACCCTGATGAACCGGGCGGTCCCCGATGCCCTCGTCGAGGGTTACGAACCGCTC
ATCGAGGCGCTGAAACTCCCCGATCTCGAAGACCGGCATGTCCTGGCCGCCGCGATCAAGGCTCAGGCCCAGGTGATCGT
CACCTCGAACCTTCGAGATTTCCCGGCCGACATGCTGGAACCCTGGAACGTGGAGGCCAAAAGCCCCGACGACTTCGTCC
TCGATCAGATCGACTTCGACGACCGGGTCGTGTGGGCGTGCGTCCAGCAGATCGTCGACTCACGGAACAACCCGCCTGAA
ACGGTCGAGGATGTGCTGGACGCTCTCGAACGCGCCGGCCTGGTCGAGTCCGTCGCGGCCTTGCGGACACGAAGTCATCG
GGGTTTTTCAACACGCGGCCTTTGA
Antitoxin
Download Length: 152 a.a. Molecular weight: 16959.33 Da Isoelectric Point: 9.9238
>AT24441 WP_012851865.1 NC_013510:1725476-1725931 [Thermomonospora curvata DSM 43183]
VADVQVRRIEPGAVDTRQAARAVQRIKAYLQRNPHEQAIRVHAEIGEEEALVLPRQAVSLFAYILSQIAAGRGVSVVPSD
AELTTQQAADLLNVSRPYLIGLLERGEIPFRRVGRHRRIRWDDLMDYKRKSEAQSRTAADELARLGQELGI
VADVQVRRIEPGAVDTRQAARAVQRIKAYLQRNPHEQAIRVHAEIGEEEALVLPRQAVSLFAYILSQIAAGRGVSVVPSD
AELTTQQAADLLNVSRPYLIGLLERGEIPFRRVGRHRRIRWDDLMDYKRKSEAQSRTAADELARLGQELGI
Download Length: 456 bp
>AT24441 NC_013510:1725476-1725931 [Thermomonospora curvata DSM 43183]
GTGGCAGACGTGCAGGTCAGGCGGATAGAGCCAGGAGCGGTCGATACCCGGCAGGCTGCGCGGGCCGTGCAGAGGATCAA
GGCGTACCTTCAGCGCAATCCTCACGAGCAGGCCATCAGGGTGCATGCTGAGATCGGTGAAGAAGAGGCCTTGGTCCTGC
CACGGCAGGCGGTGAGCTTGTTCGCCTACATCCTGTCCCAGATCGCCGCCGGGCGCGGGGTGTCGGTCGTTCCTTCAGAT
GCCGAACTGACCACGCAGCAGGCGGCCGATCTGTTGAACGTCTCCCGCCCTTATCTGATCGGGTTGCTGGAGAGGGGAGA
GATCCCCTTCAGACGGGTCGGCCGACACCGTCGCATCAGATGGGACGACTTGATGGACTATAAGCGGAAGAGCGAGGCGC
AAAGCCGCACGGCTGCCGACGAACTCGCCCGGCTCGGTCAGGAGCTGGGCATCTGA
GTGGCAGACGTGCAGGTCAGGCGGATAGAGCCAGGAGCGGTCGATACCCGGCAGGCTGCGCGGGCCGTGCAGAGGATCAA
GGCGTACCTTCAGCGCAATCCTCACGAGCAGGCCATCAGGGTGCATGCTGAGATCGGTGAAGAAGAGGCCTTGGTCCTGC
CACGGCAGGCGGTGAGCTTGTTCGCCTACATCCTGTCCCAGATCGCCGCCGGGCGCGGGGTGTCGGTCGTTCCTTCAGAT
GCCGAACTGACCACGCAGCAGGCGGCCGATCTGTTGAACGTCTCCCGCCCTTATCTGATCGGGTTGCTGGAGAGGGGAGA
GATCCCCTTCAGACGGGTCGGCCGACACCGTCGCATCAGATGGGACGACTTGATGGACTATAAGCGGAAGAGCGAGGCGC
AAAGCCGCACGGCTGCCGACGAACTCGCCCGGCTCGGTCAGGAGCTGGGCATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|