Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4824627..4825885 Replicon chromosome
Accession NZ_CP096958
Organism Pseudomonas aeruginosa strain NY11210

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2I98_RS22635 Protein ID WP_023109087.1
Coordinates 4824627..4825382 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I98_RS22640 Protein ID WP_003086329.1
Coordinates 4825517..4825885 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I98_RS22625 (M2I98_22570) 4819799..4822342 + 2544 WP_033876574.1 acyl-homoserine-lactone acylase QuiP -
M2I98_RS22630 (M2I98_22575) 4822497..4823858 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M2I98_RS22635 (M2I98_22580) 4824627..4825382 - 756 WP_023109087.1 RES family NAD+ phosphorylase Toxin
M2I98_RS22640 (M2I98_22585) 4825517..4825885 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I98_RS22645 (M2I98_22590) 4825958..4827244 - 1287 WP_054376095.1 FAD-binding oxidoreductase -
M2I98_RS22650 (M2I98_22595) 4827300..4828793 - 1494 WP_015648322.1 aldehyde dehydrogenase family protein -
M2I98_RS22655 (M2I98_22600) 4828968..4829444 + 477 WP_004353334.1 elongation factor GreAB -
M2I98_RS22660 (M2I98_22605) 4829447..4829722 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28264.40 Da        Isoelectric Point: 7.7294

>T244271 WP_023109087.1 NZ_CP096958:c4825382-4824627 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244271 WP_003086329.1 NZ_CP096958:c4825885-4825517 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References