Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2197592..2198850 Replicon chromosome
Accession NZ_CP096909
Organism Pseudomonas aeruginosa strain NY8688

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2J77_RS10425 Protein ID WP_003123189.1
Coordinates 2198095..2198850 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2J77_RS10420 Protein ID WP_003086329.1
Coordinates 2197592..2197960 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J77_RS10400 (M2J77_10390) 2193755..2194030 + 276 WP_173014646.1 zinc ribbon domain-containing protein -
M2J77_RS10405 (M2J77_10395) 2194033..2194509 - 477 WP_003112531.1 hypothetical protein -
M2J77_RS10410 (M2J77_10400) 2194588..2196177 + 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
M2J77_RS10415 (M2J77_10405) 2196233..2197519 + 1287 WP_003123190.1 FAD-binding oxidoreductase -
M2J77_RS10420 (M2J77_10410) 2197592..2197960 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2J77_RS10425 (M2J77_10415) 2198095..2198850 + 756 WP_003123189.1 RES family NAD+ phosphorylase Toxin
M2J77_RS10430 (M2J77_10420) 2199618..2200979 + 1362 WP_003081943.1 DNA recombination protein RmuC -
M2J77_RS10435 (M2J77_10425) 2201134..2203677 - 2544 WP_270145176.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28267.46 Da        Isoelectric Point: 8.3428

>T244145 WP_003123189.1 NZ_CP096909:2198095-2198850 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQKLGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244145 WP_003086329.1 NZ_CP096909:2197592-2197960 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References