Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1750177..1750790 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag M1778_RS08230 Protein ID WP_003407786.1
Coordinates 1750386..1750790 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag M1778_RS08225 Protein ID WP_009935474.1
Coordinates 1750177..1750380 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS08210 (M1778_08210) 1745441..1748344 + 2904 WP_003407779.1 MMPL family transporter -
M1778_RS08215 (M1778_08215) 1748354..1748800 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
M1778_RS08220 (M1778_08220) 1748835..1750124 + 1290 WP_003407781.1 threonine ammonia-lyase -
M1778_RS08225 (M1778_08225) 1750177..1750380 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1778_RS08230 (M1778_08230) 1750386..1750790 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
M1778_RS08235 (M1778_08235) 1750807..1752549 - 1743 WP_010950559.1 malto-oligosyltrehalose trehalohydrolase -
M1778_RS08240 (M1778_08240) 1752542..1754839 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T244048 WP_003407786.1 NZ_CP096848:1750386-1750790 [Mycobacterium tuberculosis variant bovis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT244048 WP_009935474.1 NZ_CP096848:1750177-1750380 [Mycobacterium tuberculosis variant bovis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References