Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 442087..443098 Replicon chromosome
Accession NZ_CP096845
Organism Mycobacterium tuberculosis variant bovis strain Mb1101

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag M1777_RS01940 Protein ID WP_003401859.1
Coordinates 442087..442680 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag M1777_RS01945 Protein ID WP_003401860.1
Coordinates 442709..443098 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1777_RS01920 (M1777_01920) 437736..439118 + 1383 WP_003898415.1 magnesium transporter -
M1777_RS01925 (M1777_01925) 439130..440164 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
M1777_RS01930 (M1777_01930) 440260..440943 + 684 WP_010950388.1 VTT domain-containing protein -
M1777_RS01935 (M1777_01935) 440932..442062 - 1131 WP_273585897.1 glycoside hydrolase family 76 protein -
M1777_RS01940 (M1777_01940) 442087..442680 - 594 WP_003401859.1 zeta toxin family protein Toxin
M1777_RS01945 (M1777_01945) 442709..443098 - 390 WP_003401860.1 hypothetical protein Antitoxin
M1777_RS01950 (M1777_01950) 443179..444390 - 1212 WP_003401861.1 VWA domain-containing protein -
M1777_RS01955 (M1777_01955) 444396..444998 - 603 WP_003898417.1 SRPBCC family protein -
M1777_RS01960 (M1777_01960) 445012..445908 - 897 WP_003401863.1 MoxR family ATPase -
M1777_RS01965 (M1777_01965) 445905..446498 - 594 WP_003401864.1 NTP transferase domain-containing protein -
M1777_RS01970 (M1777_01970) 446495..447250 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T243849 WP_003401859.1 NZ_CP096845:c442680-442087 [Mycobacterium tuberculosis variant bovis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T243849 NZ_OX637964:3696734-3696952 [Escherichia coli O25b:H4-ST131]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT243849 WP_003401860.1 NZ_CP096845:c443098-442709 [Mycobacterium tuberculosis variant bovis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT243849 NZ_OX637964:3696334-3696708 [Escherichia coli O25b:H4-ST131]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References