Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3739059..3739588 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag M1776_RS17590 Protein ID WP_003417760.1
Coordinates 3739331..3739588 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag M1776_RS17585 Protein ID WP_003417757.1
Coordinates 3739059..3739334 (+) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS17550 (M1776_17555) 3735632..3736321 - 690 WP_003917774.1 BBE domain-containing protein -
M1776_RS17555 (M1776_17560) 3736508..3736879 - 372 WP_003417739.1 FAD-binding protein -
M1776_RS17560 (M1776_17565) 3736777..3736995 - 219 WP_157132559.1 hypothetical protein -
M1776_RS17565 (M1776_17570) 3737022..3737282 - 261 WP_003417741.1 hypothetical protein -
M1776_RS17570 (M1776_17575) 3737397..3737786 + 390 WP_010950876.1 DUF732 domain-containing protein -
M1776_RS17575 (M1776_17580) 3737800..3738093 - 294 WP_003417749.1 DUF3017 domain-containing protein -
M1776_RS17580 (M1776_17585) 3738090..3738935 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
M1776_RS17585 (M1776_17590) 3739059..3739334 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
M1776_RS17590 (M1776_17595) 3739331..3739588 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
M1776_RS17595 (M1776_17600) 3739630..3740820 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
M1776_RS17600 (M1776_17605) 3740937..3741305 + 369 WP_003417765.1 FHA domain-containing protein -
M1776_RS17605 (M1776_17610) 3741302..3741853 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
M1776_RS17610 (M1776_17615) 3741860..3742441 - 582 WP_003417769.1 ATP/GTP-binding protein -
M1776_RS17615 (M1776_17620) 3742422..3742790 - 369 WP_003417772.1 DUF742 domain-containing protein -
M1776_RS17620 (M1776_17625) 3742768..3743160 - 393 WP_011799344.1 serine protease inhibitor -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-85)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T243843 WP_003417760.1 NZ_CP096844:3739331-3739588 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T243843 NZ_OX637964:1833143-1833397 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT243843 WP_003417757.1 NZ_CP096844:3739059-3739334 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT243843 NZ_OX637964:1832895-1833146 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3OEI


Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References