Detailed information of TA system TA243827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2393027..2393556
• Replicon: chromosome
• Accession: NZ_CP096844
• Organism: Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: M1776_RS11205
• Protein ID: WP_003411124.1
• Coordinates: 2393027..2393344 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: M1776_RS11210
• Protein ID: WP_003411127.1
• Coordinates: 2393341..2393556 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1776_RS11175 (M1776_11185)	2388048..2389124	+	1077	WP_069523391.1	hypothetical protein	-
M1776_RS11180 (M1776_11190)	2389121..2389402	+	282	WP_019283661.1	DUF5703 family protein	-
M1776_RS11185 (M1776_11195)	2389438..2390511	+	1074	WP_011799246.1	quinone-dependent dihydroorotate dehydrogenase	-
M1776_RS11190 (M1776_11200)	2390516..2391046	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
M1776_RS11195 (M1776_11205)	2391094..2392440	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
M1776_RS11205 (M1776_11215)	2393027..2393344	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1776_RS11210 (M1776_11220)	2393341..2393556	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
M1776_RS11215 (M1776_11225)	2393811..2394869	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
M1776_RS11220 (M1776_11230)	2394999..2395355	-	357	WP_003411130.1	hypothetical protein	-
M1776_RS11225 (M1776_11235)	2395450..2396232	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
M1776_RS11230 (M1776_11240)	2396500..2396790	-	291	WP_003900476.1	YggT family protein	-
M1776_RS11235 (M1776_11245)	2396952..2397608	-	657	WP_003411133.1	cell division protein SepF	-
M1776_RS11240 (M1776_11250)	2397674..2398450	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T243827 WP_003411124.1 NZ_CP096844:c2393344-2393027 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T243827 NZ_OX637961:3597203-3597421 [Escherichia coli O25b:H4-ST131]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT243827 WP_003411127.1 NZ_CP096844:c2393556-2393341 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT243827 NZ_OX637961:3596803-3597177 [Escherichia coli O25b:H4-ST131]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4