Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2247342..2247968 Replicon chromosome
Accession NZ_CP096844
Organism Mycobacterium tuberculosis variant bovis strain Mb1855

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag M1776_RS10525 Protein ID WP_003410075.1
Coordinates 2247570..2247968 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1776_RS10520 Protein ID WP_019283586.1
Coordinates 2247342..2247569 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1776_RS10510 (M1776_10515) 2245381..2245725 - 345 WP_003410065.1 ferredoxin family protein -
M1776_RS10515 (M1776_10520) 2245914..2247083 - 1170 WP_003899126.1 ATP-binding protein -
M1776_RS10520 (M1776_10525) 2247342..2247569 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1776_RS10525 (M1776_10530) 2247570..2247968 + 399 WP_003410075.1 PIN domain nuclease Toxin
M1776_RS10530 (M1776_10535) 2248151..2248582 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
M1776_RS10535 (M1776_10540) 2248683..2249117 + 435 WP_003914358.1 DUF1398 domain-containing protein -
M1776_RS10540 (M1776_10545) 2249554..2249733 - 180 Protein_2083 hypothetical protein -
M1776_RS10545 (M1776_10550) 2249821..2250441 + 621 WP_003410086.1 IS110 family transposase -
M1776_RS10550 (M1776_10555) 2250395..2250985 + 591 WP_003899131.1 IS110 family transposase -
M1776_RS10555 (M1776_10560) 2251113..2252369 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T243823 WP_003410075.1 NZ_CP096844:2247570-2247968 [Mycobacterium tuberculosis variant bovis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T243823 NZ_OX637961:2664855-2664962 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT243823 WP_019283586.1 NZ_CP096844:2247342-2247569 [Mycobacterium tuberculosis variant bovis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT243823 NZ_OX637961:c2664798-2664743 [Escherichia coli O25b:H4-ST131]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References