Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2203734..2204602 | Replicon | chromosome |
| Accession | NZ_CP096844 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb1855 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | M1776_RS10275 | Protein ID | WP_010886136.1 |
| Coordinates | 2203734..2204111 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | M1776_RS10280 | Protein ID | WP_003409886.1 |
| Coordinates | 2204153..2204602 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1776_RS10225 (M1776_10230) | 2199523..2199975 | - | 453 | WP_010950636.1 | lipoprotein | - |
| M1776_RS10230 (M1776_10235) | 2200039..2200440 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| M1776_RS10235 (M1776_10240) | 2200433..2200615 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| M1776_RS10240 (M1776_10245) | 2200729..2201079 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1776_RS10245 (M1776_10250) | 2201090..2201992 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| M1776_RS10250 (M1776_10255) | 2202013..2202204 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1776_RS10255 (M1776_10260) | 2202205..2202501 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1776_RS10260 (M1776_10265) | 2202741..2202956 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1776_RS10265 (M1776_10270) | 2202953..2203264 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1776_RS10270 (M1776_10275) | 2203238..2203759 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1776_RS10275 (M1776_10280) | 2203734..2204111 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| M1776_RS10280 (M1776_10285) | 2204153..2204602 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| M1776_RS10285 (M1776_10290) | 2204599..2205144 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1776_RS10290 (M1776_10295) | 2205033..2205647 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1776_RS10295 (M1776_10300) | 2205696..2205992 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M1776_RS10300 (M1776_10305) | 2205989..2206240 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| M1776_RS10305 (M1776_10310) | 2206227..2206721 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1776_RS10310 (M1776_10315) | 2206881..2207288 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1776_RS10315 (M1776_10320) | 2207292..2207564 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1776_RS10320 (M1776_10325) | 2207597..2208817 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T243818 WP_010886136.1 NZ_CP096844:2203734-2204111 [Mycobacterium tuberculosis variant bovis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T243818 NZ_OX637961:1902224-1902475 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT243818 WP_003409886.1 NZ_CP096844:2204153-2204602 [Mycobacterium tuberculosis variant bovis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT243818 NZ_OX637961:1902472-1902726 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|