243628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1016752..1017371 Replicon chromosome
Accession NZ_CP096841
Organism Mycobacterium tuberculosis variant bovis strain Mb0820

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag M1774_RS04835 Protein ID WP_003404726.1
Coordinates 1016937..1017371 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag M1774_RS04830 Protein ID WP_003404724.1
Coordinates 1016752..1016931 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1774_RS04815 (M1774_04815) 1012225..1013805 + 1581 WP_011799139.1 serine hydrolase -
M1774_RS04820 (M1774_04820) 1013802..1016195 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
M1774_RS04825 (M1774_04825) 1016468..1016626 + 159 WP_003404720.1 hypothetical protein -
M1774_RS04830 (M1774_04830) 1016752..1016931 + 180 WP_003404724.1 antitoxin Antitoxin
M1774_RS04835 (M1774_04835) 1016937..1017371 + 435 WP_003404726.1 SRPBCC family protein Toxin
M1774_RS04840 (M1774_04840) 1017469..1018242 + 774 WP_003404735.1 VOC family protein -
M1774_RS04845 (M1774_04845) 1018307..1018756 + 450 WP_003404738.1 hypothetical protein -
M1774_RS04850 (M1774_04850) 1018891..1019121 - 231 WP_003898642.1 hypothetical protein -
M1774_RS04855 (M1774_04855) 1019288..1020796 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
M1774_RS04860 (M1774_04860) 1020798..1022036 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T243628 WP_003404726.1 NZ_CP096841:1016937-1017371 [Mycobacterium tuberculosis variant bovis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T243628 NZ_OX419569:2318915-2319031 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT243628 WP_003404724.1 NZ_CP096841:1016752-1016931 [Mycobacterium tuberculosis variant bovis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp

>AT243628 NZ_OX419569:c2319205-2319026 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References