Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2347108..2347803 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag M1780_RS10955 Protein ID WP_003410811.1
Coordinates 2347108..2347542 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag M1780_RS10960 Protein ID WP_003410814.1
Coordinates 2347549..2347803 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS10945 (M1780_10945) 2343262..2346303 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
M1780_RS10950 (M1780_10950) 2346296..2347129 + 834 WP_003899172.1 SWIM zinc finger family protein -
M1780_RS10955 (M1780_10955) 2347108..2347542 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
M1780_RS10960 (M1780_10960) 2347549..2347803 - 255 WP_003410814.1 antitoxin Antitoxin
M1780_RS10965 (M1780_10965) 2347819..2348076 - 258 WP_003410816.1 hypothetical protein -
M1780_RS10970 (M1780_10970) 2349023..2349319 + 297 WP_003410820.1 PE family protein -
M1780_RS10975 (M1780_10975) 2349375..2350106 + 732 WP_003900467.1 PPE family protein -
M1780_RS10980 (M1780_10980) 2350646..2351392 - 747 WP_003901330.1 proteasome subunit alpha -
M1780_RS10985 (M1780_10985) 2351389..2352264 - 876 WP_003411023.1 proteasome subunit beta -
M1780_RS10990 (M1780_10990) 2352261..2352455 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T243591 WP_003410811.1 NZ_CP096840:c2347542-2347108 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T243591 NZ_OX419554:c2222097-2221846 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATTAAGGATTACTTCAGCAGCGAAGCACAAACACTAA
TCAATATAATATTCATAGTCACATGTATCATTGCCATATTGTTGTGGATCATCTATTTTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT243591 WP_003410814.1 NZ_CP096840:c2347803-2347549 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT243591 NZ_OX419554:2222075-2222175 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References