Detailed information of TA system TA243576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1387323..1387882
• Replicon: chromosome
• Accession: NZ_CP096840
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: M1780_RS06640
• Protein ID: WP_003898789.1
• Coordinates: 1387323..1387616 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: M1780_RS06645
• Protein ID: WP_003406322.1
• Coordinates: 1387613..1387882 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1780_RS06615 (M1780_06610)	1382918..1383178	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
M1780_RS06620 (M1780_06615)	1383175..1383606	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
M1780_RS06625 (M1780_06620)	1383629..1385315	-	1687	Protein_1307	PE family protein	-
M1780_RS06630 (M1780_06625)	1385495..1386355	+	861	WP_003406306.1	glycine betaine ABC transporter substrate-binding protein	-
M1780_RS06635 (M1780_06630)	1386436..1387266	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
M1780_RS06640 (M1780_06635)	1387323..1387616	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
M1780_RS06645 (M1780_06640)	1387613..1387882	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1780_RS06650 (M1780_06645)	1387995..1391690	-	3696	WP_010950509.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
M1780_RS06655 (M1780_06650)	1391832..1392620	-	789	WP_010950510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T243576 WP_003898789.1 NZ_CP096840:c1387616-1387323 [Mycobacterium tuberculosis variant bovis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T243576 NZ_OX419519:c3650107-3649826 [Kitasatospora sp. DSM 114396]
ATGGGCCACGTCACGCGCTTCACCCCGCGCGCGCAGCGGGACCTGCTGAAGATCGAGCGCTCCGACGCCCTGCGCATCCT
GCGCCGACTCGCTGACCTGCAGCGGGCGATGGACCTCGGTGACACGACGGCGTTCGACGTCAAGGCACTCCAAGGGCACG
CGGCCCGCTGGCGTCTCAGGATCGGCGACCACCGAGCGGTCTACACCGTGGAGAACGGCCAACTGATCATCTGGGTCCTG
GGCGTGGGCCACCGCAGCGACATCTACCGCCAGCTCCCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT243576 WP_003406322.1 NZ_CP096840:c1387882-1387613 [Mycobacterium tuberculosis variant bovis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT243576 NZ_OX419519:c3650383-3650114 [Kitasatospora sp. DSM 114396]
ATGATCGAGTCCATGGCCGAGGTCCGCAGCCACCTTGCCGACGTCATCGACCGGGCGCGTCGCGAGGAGACTCCGACGAT
CATCACCCGGCGCGGCAAGCAGGAGGCCGTGGTGATCGACATCGAGGAGTACCGGCGTCTCCGTCGGATAGCGGACGCTG
CCGAGGATGCCTGGCTGAATCGGCTGGCCGACGAGTCGGAGGCGGAGGGCCTGCAGGGGTCCGTTTCCCTGGAGGAGATG
GCGGCGCTCCTCCGCAGCCAGGAAGGCTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2