Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 675929..676548 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag M1780_RS03065 Protein ID WP_003403047.1
Coordinates 676141..676548 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag M1780_RS03060 Protein ID WP_003403039.1
Coordinates 675929..676144 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS03050 (M1780_03050) 674457..675215 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
M1780_RS03055 (M1780_03055) 675344..675835 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
M1780_RS03060 (M1780_03060) 675929..676144 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
M1780_RS03065 (M1780_03065) 676141..676548 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
M1780_RS03070 (M1780_03070) 676608..677294 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
M1780_RS03075 (M1780_03075) 677448..680081 + 2634 WP_273610462.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T243558 WP_003403047.1 NZ_CP096840:676141-676548 [Mycobacterium tuberculosis variant bovis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T243558 NZ_OX359239:3369243-3369836 [Alteromonas macleodii]
GTGCATCGCAATAATATCCCGTGGATATTAGATAATGGTCTTTATTGTGGTAATAGCCATGTCCAGTCACCTAATTGGGA
GGCCATAGGTAATTCGGAACTCATACAGAAACGCGCCACTCACCCAGTCCCCATATCACCATTTGGCTCTTTAAATGACT
ATGTGCCTTTCTATTTTACCCCGTTTTCCCCCATGTTGCTCAATATCAAGTCTGGACGGGGGGTTAAGCAGAGGGCTAAC
GAAGATATCGTTATATTGGTATCATCATTACACAAAGTTGAACAACTAAACTTAGATTTTGTCTATACGGACATGCATGC
ATATTATCAGTGGGCGAGTTTTTACTCGGATTTGAATCACTTGGGTGAAGTAGATTGGCCTATATTACAAACGCGGAATT
TTGCCAGAGATCTCAACGACCCAGCCAAGTTTGAACGATATCAAGCAGAAGCATTGGTAAAGCAGCATTGTCCAATAAAT
GCTTTAGTAGGTATAGCTTGTTACAATACTCGAGTTGAACAAGAGTTAAAACATCATATTCAACAGCGCAATATGAATTT
AGACGTAATTGTACGTCCAGGATGGTACTTCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT243558 WP_003403039.1 NZ_CP096840:675929-676144 [Mycobacterium tuberculosis variant bovis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT243558 NZ_OX359239:3369836-3370900 [Alteromonas macleodii]
ATGATCACTTATACGCAAGGTAATTTACTCGAAGCACAAGTAGAGGCACTCGTTAACACTGTAAATACAGTTGGAGTTAT
GGGGAAAGGTATTGCACTAATGTTCAAAGAGCGCTTTCCCAAAAACATGGCTGAATATGCTAGTGCTTGCAAAGCTAAGC
AGGTAAATACAGGTAAAATGTTTGTTACTGAAACTAGTGAGTTGATGGGTCCTAAGTGGATTGTTAATTTTCCTACTAAG
CAGCATTGGCGTGCAAAATCTAAAATGGAGTGGATCCAAGAGGGCTTAATCGATCTTCGATATTTCTTAGAAAACAACAA
TGTCCGATCAATAGCTATTCCGCCACTTGGTGCGGGACAGGGTGGACTAGCCTGGCCAGATGTAAAAATGGAGATCGAAA
AGGCTTTATCAGACATTAAAACCACAAATATTATTGTGTTTGAGCCTACCAGTAAATATCAAAACGTGGCCAAGGCATCA
GGTGTTAAGAAACTTACTCCAGCGCGAGCATTAGTTGCAGAATTAGTGAGGCGCTATTGGATTTTGGGTATGGAATGTAG
TTTGTTGGAGATTCAAAAACTCGCTTGGTTTTTACAAAGAACAATCGAAAAAAGAGGGTTAAAAAACGAATTAAAACTGA
AATTTGAAGCAAATTATTATGGACCATATGCCAATAATCTAGACCATTTACTAAATGCTCTAGATGGTAGTTATTTGAAA
TCTGATAAACGAATTCCTGATTGCGACCCGTTGGATGTGATTTGGTTTAATGAATCAGAAAAGCAAAAAATTTCAACGTA
CTTGAATACAGAAGCCAAAGAATATTTACCCGCACTCGAGGGCGCAACTCAAGTAATCAGCGGTTTCGAATCCCCTTTTG
GTTTAGAGCTTCTATCTACAGTAGATTGGTTAGTTACTAACCAAGGCTGTGAAAGGACTGTTGAATCTATTAAAGAAGGT
ATAGCTAATTGGCCTGCTGGAGCTAAATGGGCGCAAAGAAAATTTAACTTATTTAGCAATAAAGATATTGAATTTGCTTT
AACTAATTTGGAAATTCTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References