Detailed information of TA system TA243537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2841273..2841982
• Replicon: chromosome
• Accession: NZ_CP096839
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ26
• Locus tag: M1779_RS13335
• Protein ID: WP_003413164.1
• Coordinates: 2841273..2841686 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P95006
• Locus tag: M1779_RS13340
• Protein ID: WP_003413167.1
• Coordinates: 2841725..2841982 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1779_RS13305 (M1779_13305)	2836326..2837531	-	1206	WP_003413027.1	chorismate synthase	-
M1779_RS13310 (M1779_13310)	2837639..2837953	+	315	WP_009937839.1	hypothetical protein	-
M1779_RS13315 (M1779_13315)	2838249..2839460	+	1212	WP_003900845.1	alpha/beta hydrolase family protein	-
M1779_RS13320 (M1779_13320)	2839587..2840246	+	660	WP_003900846.1	LppA family lipoprotein	-
M1779_RS13325 (M1779_13325)	2840243..2840905	+	663	WP_003900848.1	LppA family lipoprotein	-
M1779_RS13330 (M1779_13330)	2840902..2841180	+	279	WP_003901422.1	type II toxin-antitoxin system VapB family antitoxin	-
M1779_RS13335 (M1779_13335)	2841273..2841686	+	414	WP_003413164.1	PIN domain nuclease	Toxin
M1779_RS13340 (M1779_13340)	2841725..2841982	+	258	WP_003413167.1	CopG family transcriptional regulator	Antitoxin
M1779_RS13345 (M1779_13345)	2841979..2842356	+	378	WP_003413174.1	type II toxin-antitoxin system VapC family toxin	-
M1779_RS13350 (M1779_13350)	2842372..2842746	-	375	WP_003413177.1	hypothetical protein	-
M1779_RS13355 (M1779_13355)	2842846..2843241	-	396	WP_003413180.1	type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20	-
M1779_RS13360 (M1779_13360)	2843238..2843483	-	246	WP_003413183.1	type II toxin-antitoxin system antitoxin VapB20	-
M1779_RS13365 (M1779_13365)	2843894..2844313	-	420	WP_003413190.1	A24 family peptidase	-
M1779_RS13370 (M1779_13370)	2844325..2845133	-	809	Protein_2639	shikimate dehydrogenase	-
M1779_RS13375 (M1779_13375)	2845130..2846383	-	1254	WP_003413196.1	endolytic transglycosylase MltG	-
M1779_RS13380 (M1779_13380)	2846376..2846888	-	513	WP_003413197.1	Holliday junction resolvase RuvX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15045.00 Da
• Isoelectric Point: 5.4673

>T243537 WP_003413164.1 NZ_CP096839:2841273-2841686 [Mycobacterium tuberculosis variant bovis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Nucleotide

• Length: 414 bp

>T243537 NZ_OX359182:c300532-300430 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9453.63 Da
• Isoelectric Point: 10.6555

>AT243537 WP_003413167.1 NZ_CP096839:2841725-2841982 [Mycobacterium tuberculosis variant bovis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Nucleotide

• Length: 258 bp

>AT243537 NZ_OX359182:300423-300568 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: G0TQ26

Antitoxin

• AlphaFold DB: A0A829C9W5