Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2208248..2208936 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag M1779_RS10335 Protein ID WP_003409958.1
Coordinates 2208248..2208667 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag M1779_RS10340 Protein ID WP_003409968.1
Coordinates 2208676..2208936 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS10305 (M1779_10310) 2203254..2203559 + 306 Protein_2036 ABC transporter permease -
M1779_RS10310 (M1779_10315) 2203555..2203635 + 81 Protein_2037 hypothetical protein -
M1779_RS10315 (M1779_10320) 2203743..2204591 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
M1779_RS10320 (M1779_10325) 2204554..2205999 - 1446 WP_003409946.1 APC family permease -
M1779_RS10325 (M1779_10330) 2206178..2206864 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
M1779_RS10330 (M1779_10335) 2207055..2208023 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
M1779_RS10335 (M1779_10340) 2208248..2208667 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
M1779_RS10340 (M1779_10345) 2208676..2208936 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1779_RS10345 (M1779_10350) 2209079..2210755 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
M1779_RS10350 (M1779_10355) 2210743..2211396 - 654 WP_003409976.1 cutinase Cfp21 -
M1779_RS10355 (M1779_10360) 2211511..2211741 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1779_RS10360 (M1779_10365) 2211826..2212737 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1779_RS10365 (M1779_10370) 2212846..2213445 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T243527 WP_003409958.1 NZ_CP096839:c2208667-2208248 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T243527 NZ_OX359175:2514595-2514912 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT243527 WP_003409968.1 NZ_CP096839:c2208936-2208676 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT243527 NZ_OX359175:2514988-2515284 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References