Detailed information of TA system TA243511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1012108..1012727
• Replicon: chromosome
• Accession: NZ_CP096839
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: M1779_RS04815
• Protein ID: WP_003404726.1
• Coordinates: 1012293..1012727 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: G0TFQ5
• Locus tag: M1779_RS04810
• Protein ID: WP_003404724.1
• Coordinates: 1012108..1012287 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1779_RS04795 (M1779_04800)	1007581..1009161	+	1581	WP_011799139.1	serine hydrolase	-
M1779_RS04800 (M1779_04805)	1009158..1011551	+	2394	WP_003898639.1	cation-translocating P-type ATPase	-
M1779_RS04805 (M1779_04810)	1011824..1011982	+	159	WP_003404720.1	hypothetical protein	-
M1779_RS04810 (M1779_04815)	1012108..1012287	+	180	WP_003404724.1	antitoxin	Antitoxin
M1779_RS04815 (M1779_04820)	1012293..1012727	+	435	WP_003404726.1	SRPBCC family protein	Toxin
M1779_RS04820 (M1779_04825)	1012825..1013598	+	774	WP_003404735.1	VOC family protein	-
M1779_RS04825 (M1779_04830)	1013663..1014112	+	450	WP_003404738.1	hypothetical protein	-
M1779_RS04830 (M1779_04835)	1014247..1014477	-	231	WP_003898642.1	hypothetical protein	-
M1779_RS04835 (M1779_04840)	1014644..1016152	-	1509	WP_003404742.1	carotenoid oxygenase family protein	-
M1779_RS04840 (M1779_04845)	1016154..1017392	-	1239	WP_003404744.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T243511 WP_003404726.1 NZ_CP096839:1012293-1012727 [Mycobacterium tuberculosis variant bovis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T243511 NZ_OX352944:c1867196-1866939 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6394.06 Da
• Isoelectric Point: 4.3059

>AT243511 WP_003404724.1 NZ_CP096839:1012108-1012287 [Mycobacterium tuberculosis variant bovis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT243511 NZ_OX352944:c1867458-1867198 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Structures

Antitoxin

• AlphaFold DB: G0TFQ5