Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 692749..693395 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag M1779_RS03130 Protein ID WP_003403122.1
Coordinates 692749..693141 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag M1779_RS03135 Protein ID WP_003403125.1
Coordinates 693138..693395 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS03115 (M1779_03115) 688410..689937 + 1528 Protein_617 virulence factor Mce family protein -
M1779_RS03120 (M1779_03120) 690000..691142 + 1143 Protein_618 virulence factor Mce family protein -
M1779_RS03125 (M1779_03125) 691147..692697 + 1551 WP_003403119.1 MlaD family protein -
M1779_RS03130 (M1779_03130) 692749..693141 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
M1779_RS03135 (M1779_03135) 693138..693395 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
M1779_RS03140 (M1779_03140) 693578..694813 - 1236 WP_273585648.1 ATP-binding protein -
M1779_RS03145 (M1779_03145) 695064..695477 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
M1779_RS03150 (M1779_03150) 695474..695710 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
M1779_RS03155 (M1779_03155) 695814..696320 - 507 WP_003900973.1 two component system sensor kinase HK1 -
M1779_RS03160 (M1779_03160) 696434..696964 - 531 WP_003917320.1 two component system sensor kinase HK2 -
M1779_RS03165 (M1779_03165) 696948..697643 - 696 WP_197044064.1 two-component system response regulator TcrA -
M1779_RS03170 (M1779_03170) 697766..698077 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T243500 WP_003403122.1 NZ_CP096839:c693141-692749 [Mycobacterium tuberculosis variant bovis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T243500 NZ_OX352941:435294-436070 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGAAGAGTTTCAGAAGGCCTTGCAGCGAACTATTAGGGCCCAAAGTCGTGGGAAGAC
GATTCCAAATCAACCGAGAGCCATTTTACTTGGAGGTCAGAGCGGAGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCCTTGCAAGAT
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGCACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTTGAAAGCGATAAACTCTTTGACCAAATTCAGATTTATCAAAGAGATCGAACTTGTATCTACGATTCTG
AAACTGATGAAGGCTCCGCAGCAGAGGTTCTTCAAAACTGTCTTTTCGGGAAGTGGAGTAAGGTTGAGGAAGAGATGTTG
AAGGTAGGACAGGAACGGTTGGGGGAATTAGTTTCAGCTAATGGAGAGAAGAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT243500 WP_003403125.1 NZ_CP096839:c693395-693138 [Mycobacterium tuberculosis variant bovis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT243500 NZ_OX352941:434818-435294 [Streptococcus suis]
ATGATTGGAGACAACATCAAGTCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGAACCAGCACCGTATCAACAGAACTCATCGACCGCATTTGTCAAAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAAGATAGTCAAGACATCGCCTTTGATGATGA
ATCGAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACCTTCGATG
AAATAGAGCGCTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATTGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References