Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 444819..445830 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag M1779_RS01945 Protein ID WP_003401859.1
Coordinates 444819..445412 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag M1779_RS01950 Protein ID WP_003401860.1
Coordinates 445441..445830 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS01925 (M1779_01925) 440468..441850 + 1383 WP_003898415.1 magnesium transporter -
M1779_RS01930 (M1779_01930) 441862..442896 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
M1779_RS01935 (M1779_01935) 442992..443675 + 684 WP_010950388.1 VTT domain-containing protein -
M1779_RS01940 (M1779_01940) 443664..444794 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
M1779_RS01945 (M1779_01945) 444819..445412 - 594 WP_003401859.1 zeta toxin family protein Toxin
M1779_RS01950 (M1779_01950) 445441..445830 - 390 WP_003401860.1 hypothetical protein Antitoxin
M1779_RS01955 (M1779_01955) 445911..447122 - 1212 WP_003401861.1 VWA domain-containing protein -
M1779_RS01960 (M1779_01960) 447128..447730 - 603 WP_003898417.1 SRPBCC family protein -
M1779_RS01965 (M1779_01965) 447744..448640 - 897 WP_003401863.1 MoxR family ATPase -
M1779_RS01970 (M1779_01970) 448637..449230 - 594 WP_003401864.1 NTP transferase domain-containing protein -
M1779_RS01975 (M1779_01975) 449227..449982 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T243498 WP_003401859.1 NZ_CP096839:c445412-444819 [Mycobacterium tuberculosis variant bovis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T243498 NZ_OX352941:238206-238466 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT243498 WP_003401860.1 NZ_CP096839:c445830-445441 [Mycobacterium tuberculosis variant bovis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT243498 NZ_OX352941:237983-238204 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References