Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 5380117..5381027 Replicon chromosome
Accession NZ_CP096810
Organism Klebsiella pneumoniae strain Bio19

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag MOV22_RS26285 Protein ID WP_004026354.1
Coordinates 5380557..5381027 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag MOV22_RS26280 Protein ID WP_004026357.1
Coordinates 5380117..5380560 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV22_RS26235 (5375894) 5375894..5376220 - 327 WP_004201125.1 C2H2-type zinc finger protein -
MOV22_RS26240 (5376402) 5376402..5376683 + 282 WP_001568067.1 hypothetical protein -
MOV22_RS26245 (5376737) 5376737..5377348 + 612 WP_000176305.1 DUF2913 family protein -
MOV22_RS26250 (5377345) 5377345..5377476 - 132 Protein_5163 ISNCY family transposase -
MOV22_RS26255 (5377533) 5377533..5378525 - 993 WP_001145103.1 hypothetical protein -
MOV22_RS26260 (5378574) 5378574..5378729 - 156 WP_000075580.1 hypothetical protein -
MOV22_RS26265 (5378870) 5378870..5378944 + 75 Protein_5166 IS6 family transposase -
MOV22_RS26270 (5378914) 5378914..5379006 + 93 Protein_5167 IS1 family transposase -
MOV22_RS26275 (5379021) 5379021..5380016 + 996 Protein_5168 translesion error-prone DNA polymerase V subunit UmuC -
MOV22_RS26280 (5380117) 5380117..5380560 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
MOV22_RS26285 (5380557) 5380557..5381027 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
MOV22_RS26290 (5381482) 5381482..5381670 - 189 WP_024198076.1 hypothetical protein -
MOV22_RS26295 (5382282) 5382282..5382542 - 261 WP_004026352.1 hypothetical protein -
MOV22_RS26305 (5385810) 5385810..5385965 + 156 Protein_5173 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - tufA 5341017..5396147 55130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T243376 WP_004026354.1 NZ_CP096810:5380557-5381027 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T243376 NZ_OX030701:c4996881-4996774 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACTGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT243376 WP_004026357.1 NZ_CP096810:5380117-5380560 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT243376 NZ_OX030701:4996929-4996995 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References