Detailed information of TA system TA243304

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 497730..498383
• Replicon: chromosome
• Accession: NZ_CP096727
• Organism: Acinetobacter baumannii strain 5732

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1S58_RS02515
• Protein ID: WP_000607077.1
• Coordinates: 497994..498383 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1S58_RS02510
• Protein ID: WP_001288210.1
• Coordinates: 497730..497987 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S58_RS02490 (M1S58_02490)	493246..494253	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
M1S58_RS02495 (M1S58_02495)	494272..494649	+	378	WP_001216380.1	50S ribosomal protein L17	-
M1S58_RS02500 (M1S58_02500)	494831..496321	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1S58_RS02505 (M1S58_02505)	496370..497542	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1S58_RS02510 (M1S58_02510)	497730..497987	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1S58_RS02515 (M1S58_02515)	497994..498383	+	390	WP_000607077.1	membrane protein	Toxin
M1S58_RS02520 (M1S58_02520)	499153..500238	+	1086	WP_000049106.1	hypothetical protein	-
M1S58_RS02525 (M1S58_02525)	500316..500882	+	567	WP_000651538.1	rhombosortase	-
M1S58_RS02530 (M1S58_02530)	501070..503265	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243304 WP_000607077.1 NZ_CP096727:497994-498383 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243304 NZ_OW970530:4026535-4026753 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243304 WP_001288210.1 NZ_CP096727:497730-497987 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243304 NZ_OW970530:4026134-4026508 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7