Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 176738..177260 Replicon plasmid pKP20-558-1
Accession NZ_CP096264
Organism Klebsiella quasipneumoniae strain KP20-558

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag M0M92_RS27335 Protein ID WP_014839901.1
Coordinates 176738..177022 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag M0M92_RS27340 Protein ID WP_014839900.1
Coordinates 177012..177260 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M92_RS27300 (M0M92_27310) 172107..173087 + 981 WP_042934497.1 IS5-like element IS5 family transposase -
M0M92_RS27305 (M0M92_27315) 173291..173812 + 522 WP_048336588.1 hypothetical protein -
M0M92_RS27310 (M0M92_27320) 173809..174411 + 603 WP_014839902.1 HAD domain-containing protein -
M0M92_RS29930 174652..175371 + 720 WP_042934502.1 cation:proton antiporter -
M0M92_RS27325 (M0M92_27335) 175388..176065 - 678 WP_042934501.1 hypothetical protein -
M0M92_RS27330 (M0M92_27340) 176071..176547 - 477 WP_042934526.1 hypothetical protein -
M0M92_RS27335 (M0M92_27345) 176738..177022 - 285 WP_014839901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0M92_RS27340 (M0M92_27350) 177012..177260 - 249 WP_014839900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M0M92_RS27345 (M0M92_27355) 177559..179091 - 1533 WP_064386399.1 IS3 family transposase -
M0M92_RS27350 (M0M92_27360) 179203..180606 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
M0M92_RS27355 (M0M92_27365) 180635..181267 - 633 WP_001567369.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS1 / tet(D) / aac(3)-IId / sul2 - 1..232977 232977
- inside IScluster/Tn - - 172107..180606 8499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T243029 WP_014839901.1 NZ_CP096264:c177022-176738 [Klebsiella quasipneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

>T243029 NZ_OW968328:c3941279-3940866 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCGCTGTGGCTGTTGTTGCTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATCAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGTCAG
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGACGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGAACTGCGCCGGATGCTACTGCAGCAGCAAC
CGACGCAGGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT243029 WP_014839900.1 NZ_CP096264:c177260-177012 [Klebsiella quasipneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp

>AT243029 NZ_OW968328:c3941526-3941260 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EVH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EVH5

References