Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 121795..122372 | Replicon | plasmid pPre20-95-1 |
| Accession | NZ_CP096259 | ||
| Organism | Providencia rettgeri strain Pre20-95 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | U5N651 |
| Locus tag | M0M83_RS21365 | Protein ID | WP_023159957.1 |
| Coordinates | 122040..122372 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | U5N340 |
| Locus tag | M0M83_RS21360 | Protein ID | WP_023159984.1 |
| Coordinates | 121795..122040 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M0M83_RS21325 (M0M83_21330) | 117530..118576 | + | 1047 | WP_099660672.1 | ParB/RepB/Spo0J family partition protein | - |
| M0M83_RS21330 (M0M83_21335) | 118579..118923 | + | 345 | WP_099660671.1 | single-stranded DNA-binding protein | - |
| M0M83_RS21335 (M0M83_21340) | 118916..119338 | + | 423 | WP_099660670.1 | hypothetical protein | - |
| M0M83_RS21340 (M0M83_21345) | 119348..119917 | + | 570 | WP_282561537.1 | hypothetical protein | - |
| M0M83_RS21345 (M0M83_21350) | 120091..120459 | + | 369 | WP_099660668.1 | hypothetical protein | - |
| M0M83_RS21350 (M0M83_21355) | 120557..120784 | - | 228 | WP_048607652.1 | plasmid partition protein ParG | - |
| M0M83_RS21355 (M0M83_21360) | 120899..121522 | - | 624 | WP_048607650.1 | ParA family partition ATPase | - |
| M0M83_RS21360 (M0M83_21365) | 121795..122040 | + | 246 | WP_023159984.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| M0M83_RS21365 (M0M83_21370) | 122040..122372 | + | 333 | WP_023159957.1 | endoribonuclease MazF | Toxin |
| M0M83_RS21370 (M0M83_21375) | 122403..122783 | + | 381 | WP_048821763.1 | hypothetical protein | - |
| M0M83_RS21375 (M0M83_21380) | 122871..123011 | - | 141 | WP_072022937.1 | Hok/Gef family protein | - |
| M0M83_RS21380 (M0M83_21385) | 123331..123789 | - | 459 | WP_248468487.1 | hypothetical protein | - |
| M0M83_RS21385 (M0M83_21390) | 123888..124142 | - | 255 | WP_048821760.1 | hypothetical protein | - |
| M0M83_RS21390 (M0M83_21395) | 124157..124450 | - | 294 | WP_282558512.1 | hypothetical protein | - |
| M0M83_RS21395 (M0M83_21400) | 124744..125697 | + | 954 | WP_099660724.1 | site-specific integrase | - |
| M0M83_RS21400 (M0M83_21405) | 125713..126528 | + | 816 | WP_248468488.1 | DUF4365 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | catB8 / blaOXA-10 / ant(3'')-Ia / qacE / sul1 / mph(E) / msr(E) / armA / qnrA1 / blaNDM-1 / aadA5 / catA1 | - | 1..129768 | 129768 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12097.88 Da Isoelectric Point: 7.0813
>T242993 WP_023159957.1 NZ_CP096259:122040-122372 [Providencia rettgeri]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG
Download Length: 333 bp
>T242993 NZ_OW968280:c1323671-1323297 [Klebsiella oxytoca]
ATGCAAATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCAAAATCTGGCAAAAATTACTGGA
GTATCTGCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAACACATTG
ATGCGGGAATCTCACTGTGTGACGCTGTGAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTC
AGCGTGAAAGAGCAGTCTCCGTTTATCGGCAGCCTTGATATGCTCCGAGACCGGAAGGCTACCGGGCTGATGACCCGCAA
GGGATATAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA
ATGCAAATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCAAAATCTGGCAAAAATTACTGGA
GTATCTGCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAACACATTG
ATGCGGGAATCTCACTGTGTGACGCTGTGAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTC
AGCGTGAAAGAGCAGTCTCCGTTTATCGGCAGCCTTGATATGCTCCGAGACCGGAAGGCTACCGGGCTGATGACCCGCAA
GGGATATAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8786.20 Da Isoelectric Point: 5.0351
>AT242993 WP_023159984.1 NZ_CP096259:121795-122040 [Providencia rettgeri]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLDNLLAGITPENIHEKVDFGARTGKEL
I
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLDNLLAGITPENIHEKVDFGARTGKEL
I
Download Length: 246 bp
>AT242993 NZ_OW968280:c1324069-1323710 [Klebsiella oxytoca]
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCGCGGAACCCTGGTGGGGCCTCAGACGCAACGTCACGCCATGTTT
TGGTGCCCGGCTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCAGCACCACCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGTTACTGATGAAGCAGATGGAGCTCATGCTGACCAGCAGCGAACTCATG
CCCCGCATTCAGCGCTGCATCACGCTCCATGCAAAAGGGCTGATATGTAAGGCCGATACGCTCGGTTCCTGTGGCTATTT
GTATATCGTAATTTATCCGGCGTCTGCAACAACCGCATAA
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCGCGGAACCCTGGTGGGGCCTCAGACGCAACGTCACGCCATGTTT
TGGTGCCCGGCTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCAGCACCACCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGTTACTGATGAAGCAGATGGAGCTCATGCTGACCAGCAGCGAACTCATG
CCCCGCATTCAGCGCTGCATCACGCTCCATGCAAAAGGGCTGATATGTAAGGCCGATACGCTCGGTTCCTGTGGCTATTT
GTATATCGTAATTTATCCGGCGTCTGCAACAACCGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2P1BQ75 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A857E7M9 |